Linked Life Data

11303315

Source:http://linkedlifedata.com/resource/pubmed/id/11303315

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-4-16
pubmed:abstractText
In a multicenter study 142 patients (from 8 centers) with type 2 diabetes (77 men and 65 women, mean age 57 +/- 8.5 (SD) yrs, mean duration of diabetes 64.4 +/- 57.7 months, mean BMI 28.7 +/- 3.6 kg/m2) received over 3 months as the only antidiabetic drug glymepiride (Amaryl) once daily before breakfast in the dose of 0.5-7.0 mg, but mostly 1-3 mg. The treatment was interrupted in one patient due to metabolic deterioration which needed insulin therapy, in an other one because of allergic eruption, and in two because of insufficient compliance. In all other patients the satisfactory decrease of glyceaemia in fasting state and over the day was obtained: the median value of the mean daily glycemia decreased from 8.8 mmol/l (158 mg/dl) to 7.2 mmol/l (129 mg/dl), p < 0.001, of the mean Mw index from 12 to 8.2, p < 0.001, also the median value of HbA1c diminished from 8.0 to 7.35%, p < 0.001. These effects were particularly evident in a subgroup of 28 patients with diabetes duration below 1.5 yrs: at the end of the study no one blood glucose value in the daily profile did exceed 7.7 mmol/l (140 mg/dl). No significant change of BMI, serum triglycerides and serum total cholesterol was observed, instead a significant decrease of mean systolic and diastolic blood pressure took place (from 143 +/- 20 to 136 +/- 17 mm Hg, p < 0.001, and from 85 +/- 10 to 83 +/- 9 mm Hg, p < 0.001, respectively). The tolerance of the drug was good. The verified hypoglycaemia developed in one patient (0.7%). No changes of the laboratory safety parameters were observed.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0032-3772
pubmed:author
pubmed:issnType
Print
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
489-96
pubmed:dateRevised
2010-4-1
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
[Clinical evaluation of glimepiride in treatment of type 2 diabetes. Results of a multicenter study].
pubmed:affiliation
Oddzia? Chorób Wewnetrznych i Diabetologii CSK MSWiA ul. Wo?oska 137 02-507 Warszawa.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Multicenter Study