Linked Life Data

11302566

Source:http://linkedlifedata.com/resource/pubmed/id/11302566

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-4-13
pubmed:abstractText
A dysfunction of central dopaminergic neurotransmission has been found in various neuropsychiatric diseases, and may be associated with a common psychopathological correlate. One hypothesis suggests that dopaminergic stimulation of the brain reward system reinforces behavior because it is experienced as pleasurable, and that dopaminergic dysfunction leads to anhedonia, the inability to experience pleasure. An alternative hypothesis assumes that dopaminergic stimulation does not promote pleasure or "liking" of a reward but rather mediates "wanting" of a reward, and suggests that dopaminergic dysfunction is associated with a failure to be motivated by stimuli that indicate reward. We measured negative symptoms, psychomotor slowing and dopamine receptor sensitivity in twelve drug-free patients with major depression, seventeen alcohol-dependent and sixteen opiate-dependent patients, ten schizophrenics with neuroleptic medication, and ten healthy controls. The sensitivity of central dopamine receptors was assessed with the growth hormone response to apomorphine application. Psychomotor slowing was measured in a reaction-time test and anhedonia and other negative symptoms were assessed with self-rating scales and the Scale for the Assessment of Negative Symptoms. Patients with major depression, alcohol dependence and neuroleptic medication displayed a reduced sensitivity of central dopamine receptors compared to control subjects. Anhedonia was not a common correlate of dopamine receptor dysfunction. Instead, affective flattening was associated with both dopamine receptor sensitivity and psychomotor slowing. Our findings thus do not support the anhedonia hypothesis of central dopaminergic dysfunction. Rather, affective flattening may result from the lack of an emotional response towards reward-indicating stimuli. These findings indicate that patients with dopaminergic dysfunction are not unable to experience pleasure, but may fail to be motivated by environmental stimuli to seek reward.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0176-3679
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
66-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11302566-Adult, pubmed-meshheading:11302566-Affect, pubmed-meshheading:11302566-Alcoholism, pubmed-meshheading:11302566-Apomorphine, pubmed-meshheading:11302566-Corticotropin-Releasing Hormone, pubmed-meshheading:11302566-Depressive Disorder, pubmed-meshheading:11302566-Dopamine Agonists, pubmed-meshheading:11302566-Female, pubmed-meshheading:11302566-Hormones, pubmed-meshheading:11302566-Humans, pubmed-meshheading:11302566-Male, pubmed-meshheading:11302566-Middle Aged, pubmed-meshheading:11302566-Motivation, pubmed-meshheading:11302566-Opioid-Related Disorders, pubmed-meshheading:11302566-Psychomotor Performance, pubmed-meshheading:11302566-Reaction Time, pubmed-meshheading:11302566-Receptors, Dopamine, pubmed-meshheading:11302566-Schizophrenia, pubmed-meshheading:11302566-Schizophrenic Psychology
pubmed:year
2001
pubmed:articleTitle
Psychopathological correlates of reduced dopamine receptor sensitivity in depression, schizophrenia, and opiate and alcohol dependence.
pubmed:affiliation
Department of Psychiatry of the Freie Universität Berlin, Germany.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't