pubmed-article:11302520 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11302520 | lifeskim:mentions | umls-concept:C0221908 | lld:lifeskim |
pubmed-article:11302520 | lifeskim:mentions | umls-concept:C0814997 | lld:lifeskim |
pubmed-article:11302520 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
pubmed-article:11302520 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
pubmed-article:11302520 | lifeskim:mentions | umls-concept:C1423108 | lld:lifeskim |
pubmed-article:11302520 | lifeskim:mentions | umls-concept:C1413301 | lld:lifeskim |
pubmed-article:11302520 | lifeskim:mentions | umls-concept:C1413945 | lld:lifeskim |
pubmed-article:11302520 | lifeskim:mentions | umls-concept:C1422804 | lld:lifeskim |
pubmed-article:11302520 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
pubmed-article:11302520 | lifeskim:mentions | umls-concept:C0597427 | lld:lifeskim |
pubmed-article:11302520 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:11302520 | pubmed:dateCreated | 2001-4-13 | lld:pubmed |
pubmed-article:11302520 | pubmed:abstractText | Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation. Cdx1and the Pancreatitis Associated Protein I (PAP I) are concomitantly expressed in the epithelial cells of the lower part of the intestinal crypts. Because Cdx1 is a transcription factor and PAP I, in other tissues, is a proliferative factor, we looked for a relationship between these two proteins in the intestinal-derived IEC-6 cells. After stable transfection with a Cdx1 expression vector, they produce high levels of the PAP I transcript and protein indicating a functional link between the two genes. Demonstration of Cdx1 binding to the PAP I promoter region and suppression of PAP I induction after deletion of the corresponding sequence indicated that Cdx1 is a transcription factor controlling PAP I gene expression in intestinal cells. By infecting IEC-6 cells with adenoviruses expressing PAP I, we demonstrated that PAP I induces mitosis in these cells. On the other hand, inhibition of the PAP I expression in the IEC-6 Cdxl-expressing cells using an antisense strategy confirmed the requirement of this protein for the effect of Cdx1 on cell growth. Finally, addition of the immunopurified PAP I to the culture medium promotes cell growth of the IEC-6 cells in a dose-dependent manner. Maximal effect was obtained at 1 ng/ml. Taken together these results demonstrate that PAP I is a target of the Cdx1 homeobox gene in intestinal cells which participates in the regulation of intestinal cell growth via an autocrine and/or paracrine mechanism. | lld:pubmed |
pubmed-article:11302520 | pubmed:language | eng | lld:pubmed |
pubmed-article:11302520 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11302520 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:11302520 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11302520 | pubmed:month | Feb | lld:pubmed |
pubmed-article:11302520 | pubmed:issn | 0171-9335 | lld:pubmed |
pubmed-article:11302520 | pubmed:author | pubmed-author:DagornJ CJC | lld:pubmed |
pubmed-article:11302520 | pubmed:author | pubmed-author:SoubeyranPP | lld:pubmed |
pubmed-article:11302520 | pubmed:author | pubmed-author:IovannaJ LJL | lld:pubmed |
pubmed-article:11302520 | pubmed:author | pubmed-author:DusettiN JNJ | lld:pubmed |
pubmed-article:11302520 | pubmed:author | pubmed-author:VasseurSS | lld:pubmed |
pubmed-article:11302520 | pubmed:author | pubmed-author:MoucadelVV | lld:pubmed |
pubmed-article:11302520 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11302520 | pubmed:volume | 80 | lld:pubmed |
pubmed-article:11302520 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11302520 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11302520 | pubmed:pagination | 156-63 | lld:pubmed |
pubmed-article:11302520 | pubmed:dateRevised | 2010-2-8 | lld:pubmed |
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pubmed-article:11302520 | pubmed:year | 2001 | lld:pubmed |
pubmed-article:11302520 | pubmed:articleTitle | Cdx1 promotes cellular growth of epithelial intestinal cells through induction of the secretory protein PAP I. | lld:pubmed |
pubmed-article:11302520 | pubmed:affiliation | Laboratoire de Recherche de Physiologie et Pathologie Digestives, INSERM U.315, Marseille, France. | lld:pubmed |
pubmed-article:11302520 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11302520 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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