Linked Life Data

11301497

Source:http://linkedlifedata.com/resource/pubmed/id/11301497

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-4-13
pubmed:abstractText
The origin of perivascular nerve fibres storing nitric oxide synthase (NOS) and co-localisation with perivascular neuropeptides were examined in the rat middle cerebral artery (MCA) by retrograde tracing with True Blue (TB) in combination with immunocytochemistry. Application of TB to the proximal part of the middle cerebral artery labelled nerve cell bodies ipsilaterally in the trigeminal, sphenopalatine, otic, and superior cervical ganglia. A few labelled cell bodies were seen contralaterally, suggesting bilateral innervation. In the parasympathetic sphenopalatine and otic ganglia, numerous TB-labelled cell bodies contained neuronal NOS (C- and N-terminal), vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase activating peptide (PACAP). In the trigeminal ganglion, almost all TB-labelled cell bodies contained calcitonin gene-related peptide (CGRP) but only a few cells contained NOS. In the superior cervical ganglion, the majority of the TB-labelled nerve cells contained neuropeptide Y (NPY) but none of them contained NOS. Removal of the ipsilateral sphenopalatine ganglion caused a slight reduction in the number of perivascular VIP-, PACAP-, and NOS-containing fibres after 3 days in the MCA while there was no difference at 2 and 4 weeks after the denervation as compared to control. This indicates that the parasympathetic VIP-, PACAP-, and NOS-immunoreactive nerve fibres in the rat MCA originate from several sources.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1059-910X
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11301497-Animals, pubmed-meshheading:11301497-Benzofurans, pubmed-meshheading:11301497-Calcitonin Gene-Related Peptide, pubmed-meshheading:11301497-Cerebral Arteries, pubmed-meshheading:11301497-Denervation, pubmed-meshheading:11301497-Fluorescent Antibody Technique, pubmed-meshheading:11301497-Fluorescent Dyes, pubmed-meshheading:11301497-Ganglia, Parasympathetic, pubmed-meshheading:11301497-Immunohistochemistry, pubmed-meshheading:11301497-Male, pubmed-meshheading:11301497-Middle Cerebral Artery, pubmed-meshheading:11301497-Nerve Fibers, pubmed-meshheading:11301497-Neuropeptides, pubmed-meshheading:11301497-Nitric Oxide Synthase, pubmed-meshheading:11301497-Pituitary Adenylate Cyclase-Activating Polypeptide, pubmed-meshheading:11301497-Rats, pubmed-meshheading:11301497-Rats, Sprague-Dawley, pubmed-meshheading:11301497-Superior Cervical Ganglion, pubmed-meshheading:11301497-Trigeminal Ganglion, pubmed-meshheading:11301497-Vasoactive Intestinal Peptide
pubmed:year
2001
pubmed:articleTitle
Origin and Co-localization of nitric oxide synthase, CGRP, PACAP, and VIP in the cerebral circulation of the rat.
pubmed:affiliation
Department of Internal Medicine, University of Lund, S-221 85 Lund, Sweden. lars.edvinsson@med.lu.se
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't