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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-4-13
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pubmed:abstractText |
These data show that 8-Cl-cAMP is cytotoxic to the lymphoblastic leukemia cell line CEM and its vinblastine selected multidrug resistant derivative, CEM/VLB100 although PKA was not involved in these effects. The cytotoxic effects of 8-Cl-cAMP was abrogated by cotreatment with either ADA or IBMX which indicated a degradation form of 8-Cl-cAMP was needed for this cytotoxicity. CEM and CEM/VLB100 cells displayed a notable sensitivity to 8-Cl-adenosine-induced growth inhibition and apoptosis. 8-Cl-adenosine increased the cytosolic levels of IkappaBalpha which prevented NF-kappaB nuclear translocation. 8-Cl-adenosine also prevented TNFalpha-induced IkB decay and NF-kappaB activation in CEM and CEM/VLB100 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Chloroadenosine,
http://linkedlifedata.com/resource/pubmed/chemical/8-Bromo Cyclic Adenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/8-chloro-cyclic adenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/8-chloroadenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Vinblastine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0145-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
423-31
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pubmed:dateRevised |
2006-4-24
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pubmed:meshHeading |
pubmed-meshheading:11301111-2-Chloroadenosine,
pubmed-meshheading:11301111-8-Bromo Cyclic Adenosine Monophosphate,
pubmed-meshheading:11301111-Antineoplastic Agents,
pubmed-meshheading:11301111-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:11301111-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11301111-Apoptosis,
pubmed-meshheading:11301111-Biotransformation,
pubmed-meshheading:11301111-Cell Division,
pubmed-meshheading:11301111-Cell Nucleus,
pubmed-meshheading:11301111-DNA-Binding Proteins,
pubmed-meshheading:11301111-Dose-Response Relationship, Drug,
pubmed-meshheading:11301111-Drug Resistance, Neoplasm,
pubmed-meshheading:11301111-Growth Inhibitors,
pubmed-meshheading:11301111-Humans,
pubmed-meshheading:11301111-I-kappa B Proteins,
pubmed-meshheading:11301111-Leukemia, T-Cell,
pubmed-meshheading:11301111-NF-kappa B,
pubmed-meshheading:11301111-Tumor Necrosis Factor-alpha,
pubmed-meshheading:11301111-Up-Regulation,
pubmed-meshheading:11301111-Vinblastine
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pubmed:year |
2001
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pubmed:articleTitle |
8-Cl-adenosine mediated cytotoxicity and sensitization of T-lymphoblastic leukemia cells to TNFalpha-induced apoptosis is via inactivation of NF-kappaB.
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pubmed:affiliation |
Department of Haematology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Turner Street, E1 2AD, London, UK.
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pubmed:publicationType |
Journal Article
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