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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1B
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pubmed:dateCreated |
2001-4-12
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|
pubmed:abstractText |
Integrin alpha v-beta 3 is involved in tumor angiogenesis while the clinical significance of beta 3 integrin expression in colorectal cancer and lung metastases. Analysis was performed on 51 colorectal cancer patients (22 with subsequent lung metastasis and 29 without lung metastasis). Fifty-one primary tumors and 22 lung metastases were examined for immunohistochemical detection of integrin beta 3. We found that the antibody VNR 5 to integrin beta 3 prefentially stains the blood vessels of small caliber. Indeed, vascular integrin beta 3 index was significantly higher in tumors of patients with lung metastasis than in those without lung metastasis. In the patients with lung metastases, vascular integrin beta 3 index was significantly lower in lung metastases than in primary tumors. It was immunohistochemically proved that integrin beta 3 is an important vascular endothelial cell market for lung metastasis.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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|
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
643-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11299820-Adenocarcinoma,
pubmed-meshheading:11299820-Adult,
pubmed-meshheading:11299820-Aged,
pubmed-meshheading:11299820-Aneuploidy,
pubmed-meshheading:11299820-Antigens, CD,
pubmed-meshheading:11299820-Cell Movement,
pubmed-meshheading:11299820-Colorectal Neoplasms,
pubmed-meshheading:11299820-DNA, Neoplasm,
pubmed-meshheading:11299820-Disease-Free Survival,
pubmed-meshheading:11299820-Endothelium, Vascular,
pubmed-meshheading:11299820-Female,
pubmed-meshheading:11299820-Humans,
pubmed-meshheading:11299820-Integrin beta3,
pubmed-meshheading:11299820-Lung Neoplasms,
pubmed-meshheading:11299820-Male,
pubmed-meshheading:11299820-Middle Aged,
pubmed-meshheading:11299820-Neoplasm Invasiveness,
pubmed-meshheading:11299820-Neoplasm Proteins,
pubmed-meshheading:11299820-Neovascularization, Pathologic,
pubmed-meshheading:11299820-Platelet Membrane Glycoproteins,
pubmed-meshheading:11299820-Prognosis
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pubmed:articleTitle |
Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma.
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pubmed:affiliation |
Department of Surgery, Toyama Prefectural Central Hospital 2-2-78 Nishinagae, Toyama, 930-8550, Japan. YIB03163@niftyserve.or.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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