Source:http://linkedlifedata.com/resource/pubmed/id/11299268
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2001-4-12
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| pubmed:abstractText |
An autosomal genomewide search for genes related to body composition and its changes after a 20-wk endurance-exercise training program has been completed in the HERITAGE Family Study. Phenotypes included body mass index (BMI), sum of eight skinfold thicknesses, fat mass (FM), fat-free mass, percent body fat (%Fat), and plasma leptin levels. A maximum of 364 sib-pairs from 99 Caucasian families was studied with the use of 344 markers with single-point and multipoint linkage analyses. Evidence of significant linkage was observed for changes in fat-free mass with the S100A and the insulin-like growth factor I genes (P = 0.0001). Suggestive evidence (2.0 < or = Lod < 3.0; 0.0001 < P < or = 0.001) was also observed for the changes in FM and %Fat at 1q31 and 18q21-q23, in %Fat with the uncoupling protein 2 and 3 genes, and in BMI at 5q14-q21. At baseline, suggestive evidence was observed for BMI at 8q23-q24, 10p15, and 14q11; for FM at 14q11; and for plasma leptin levels with the low-density lipoprotein receptor gene. This is the first genomic scan on genes involved in exercise-training-induced changes in body composition that could provide information on the determinants of weight loss.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
8750-7587
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| pubmed:author |
pubmed-author:BoreckiI BIB,
pubmed-author:BouchardCC,
pubmed-author:BouchardLL,
pubmed-author:ChagnonY CYC,
pubmed-author:GagnonJJ,
pubmed-author:HERITAGE Family Study,
pubmed-author:Ho-KimM AMA,
pubmed-author:LacailleMM,
pubmed-author:LeonA SAS,
pubmed-author:PérusseLL,
pubmed-author:ParéCC,
pubmed-author:RaoD CDC,
pubmed-author:RiceTT,
pubmed-author:SkinnerJ SJS,
pubmed-author:WilmoreJ HJH
|
| pubmed:issnType |
Print
|
| pubmed:volume |
90
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1777-87
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11299268-Adipose Tissue,
pubmed-meshheading:11299268-Adolescent,
pubmed-meshheading:11299268-Adult,
pubmed-meshheading:11299268-Aged,
pubmed-meshheading:11299268-Body Composition,
pubmed-meshheading:11299268-Body Mass Index,
pubmed-meshheading:11299268-Body Weight,
pubmed-meshheading:11299268-Canada,
pubmed-meshheading:11299268-Chromosome Mapping,
pubmed-meshheading:11299268-European Continental Ancestry Group,
pubmed-meshheading:11299268-Exercise,
pubmed-meshheading:11299268-Female,
pubmed-meshheading:11299268-Genetic Markers,
pubmed-meshheading:11299268-Humans,
pubmed-meshheading:11299268-Leptin,
pubmed-meshheading:11299268-Lod Score,
pubmed-meshheading:11299268-Male,
pubmed-meshheading:11299268-Microsatellite Repeats,
pubmed-meshheading:11299268-Middle Aged,
pubmed-meshheading:11299268-Nuclear Family,
pubmed-meshheading:11299268-Physical Fitness,
pubmed-meshheading:11299268-Receptors, LDL,
pubmed-meshheading:11299268-Sex Characteristics,
pubmed-meshheading:11299268-Skinfold Thickness,
pubmed-meshheading:11299268-United States
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE.
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| pubmed:affiliation |
Department of Social and Preventive Medicine and Kinesiology, Laval University, Ste. Foy, Quebec, Canada G1K 7P4. Yvon.Chagnon@kin.msp.ulaval.ca
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|