Linked Life Data

11299202

Source:http://linkedlifedata.com/resource/pubmed/id/11299202

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-4-12
pubmed:abstractText
Bradykinin (BK) is released in the brain during injury and inflammation. Activation of endothelial BK receptors produces acute dilatation of cerebral arterioles that is mediated by reactive oxygen species (ROS). ROS can also modulate gene expression, including expression of the inducible isoform of cyclooxygenase (COX-2). We hypothesized that exposure of the brain to BK would produce acute dilatation, which would be followed by a delayed dilatation mediated by COX-2. To test this hypothesis in anesthetized rats, BK was placed twice in cranial windows for 7 min, after which the windows were flushed to remove residual BK. The two BK exposures were separated by 30 min. Each BK exposure produced acute dilatation of cerebral arterioles, after which diameter rapidly returned to baseline. Over the subsequent 4.5 h after the second BK exposure, arterioles dilated 48 +/- 8%. Treatment of the cranial window with NS-398, a selective COX-2 inhibitor, or dexamethasone, significantly attenuated the delayed dilatation. Aminoguanidine, a selective inhibitor of inducible nitric oxide synthase, did not alter the delayed dilatation. Cotreatment of cranial windows with BK, superoxide dismutase, and catalase also prevented the delayed dilatation. In separate experiments, exposure of the cortical surface to BK upregulated leptomeningeal expression of COX-2 mRNA. Our results suggest that acute, time-limited exposure of the brain to BK produces delayed dilatation of cerebral arterioles dependent on expression and activity of COX-2.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0363-6135
pubmed:author
pubmed:issnType
Print
pubmed:volume
280
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H2023-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11299202-Animals, pubmed-meshheading:11299202-Arterioles, pubmed-meshheading:11299202-Bradykinin, pubmed-meshheading:11299202-Cerebrovascular Circulation, pubmed-meshheading:11299202-Cyclooxygenase 2, pubmed-meshheading:11299202-Cyclooxygenase 2 Inhibitors, pubmed-meshheading:11299202-Cyclooxygenase Inhibitors, pubmed-meshheading:11299202-Encephalitis, pubmed-meshheading:11299202-Gene Expression Regulation, Enzymologic, pubmed-meshheading:11299202-Isoenzymes, pubmed-meshheading:11299202-Male, pubmed-meshheading:11299202-Nitrobenzenes, pubmed-meshheading:11299202-Prostaglandin-Endoperoxide Synthases, pubmed-meshheading:11299202-Rats, pubmed-meshheading:11299202-Rats, Sprague-Dawley, pubmed-meshheading:11299202-Reaction Time, pubmed-meshheading:11299202-Reactive Oxygen Species, pubmed-meshheading:11299202-Sulfonamides, pubmed-meshheading:11299202-Vasodilation
pubmed:year
2001
pubmed:articleTitle
COX-2-dependent delayed dilatation of cerebral arterioles in response to bradykinin.
pubmed:affiliation
Department of Anesthesia, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't