Source:http://linkedlifedata.com/resource/pubmed/id/11298597
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2001-4-12
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| pubmed:abstractText |
Although it has been over 25 years since HLA-DP was mapped to the major histocompatibility complex (MHC), its biological functions remain ill-defined. We sought to test the hypothesis that HLA-DP functions in a manner similar to that of other class II genes by measuring the risk of clinically severe grades III-IV acute graft-vs.-host disease (GVHD) associated with recipient HLA-DP disparity after haematopoietic cell transplantation. HLA-DPB1 exon 2 was sequenced in 205 patients who underwent transplantation from HLA-A, -B, -C, -DRB1 and -DQB1 allele-matched unrelated donors. HLA-DPB1 mismatched recipients experienced a significantly increased risk of acute GVHD compared with HLA-DP-identical transplants. Patients who were mismatched for a single HLA-DPB1 allele had an odds ratio (OR) of 1.0 (0.5, 2.2; P = 0.99) and patients who were mismatched for two alleles had an OR of 2.2 (1.0, 4.9; P = 0.06) for developing acute GVHD. Compared with matched and single-allele mismatched transplants, patients who were mismatched for two DPB1 alleles had an OR of 2.2 (1.2, 4.1; P = 0.01). HLA-DP plays an important role in the alloimmune response. A threshold effect of multiple HLA-DP disparities is evident in determining the risk of acute GVHD after haematopoietic cell transplantation from unrelated donors.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0007-1048
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
112
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
988-94
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11298597-Adolescent,
pubmed-meshheading:11298597-Adult,
pubmed-meshheading:11298597-Child,
pubmed-meshheading:11298597-Female,
pubmed-meshheading:11298597-Follow-Up Studies,
pubmed-meshheading:11298597-Graft vs Host Disease,
pubmed-meshheading:11298597-HLA-DP Antigens,
pubmed-meshheading:11298597-HLA-DP beta-Chains,
pubmed-meshheading:11298597-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11298597-Histocompatibility Testing,
pubmed-meshheading:11298597-Humans,
pubmed-meshheading:11298597-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:11298597-Male,
pubmed-meshheading:11298597-Middle Aged,
pubmed-meshheading:11298597-Odds Ratio,
pubmed-meshheading:11298597-Proportional Hazards Models,
pubmed-meshheading:11298597-Risk,
pubmed-meshheading:11298597-Transplantation, Homologous,
pubmed-meshheading:11298597-Transplantation Immunology
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| pubmed:year |
2001
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| pubmed:articleTitle |
The biological significance of HLA-DP gene variation in haematopoietic cell transplantation.
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| pubmed:affiliation |
Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D4-100, Seattle, WA 98109-1024, USA. epetersd@fhcrc.org
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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