Linked Life Data

11298113

Source:http://linkedlifedata.com/resource/pubmed/id/11298113

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-4-12
pubmed:abstractText
The cutaneous forms of lupus erythematosus (LE) are true complex traits, susceptibility to which is determined by multiple factors. Good evidence exists for both genetic and environmental components to this complexity. Several different experimental techniques have found the strongest genetic associations with cutaneous LE to include sequence polymorphisms of genes encoding HLA, TNF-alpha and complement molecules, particularly in anti-Ro-positive patients. Abnormal expression of multiple other cytokines, adhesion molecules and cellular proteins (such as Ro and La) points towards a range of candidate genes that are currently being examined in cutaneous LE. Combinations of specific polymorphisms of genes encoding these immunoregulatory molecules may determine individual susceptibility to LE.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0307-6938
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
184-91
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Molecular genetics of cutaneous lupus erythematosus.
pubmed:affiliation
Department of Photobiology, St John's Institute of Dermatology, St Thomas' Hospital, London, UK. t.millard@kcl.ac.uk
pubmed:publicationType
Journal Article, Review