Source:http://linkedlifedata.com/resource/pubmed/id/11295422
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2001-4-11
|
| pubmed:abstractText |
3-[(123)I]Iodo-L-alpha-methyl tyrosine ([(123)I]IMT) scintigraphy of extracranial malignant tumors has been described, but little is known about the transport systems involved in [(123)I]IMT uptake into extracranial tumor cells. Here, the precise kinetics of [(123)I]IMT transport into human Ewing's sarcoma cells (VH-64) was determined. The apparent Michaelis constant was of high affinity value (K(m)=41.7+/-3.9 microM) and maximum transport velocitiy amounted to V(max)=20.7+/-0.6 nmol x mg protein(-1) x 10 min(-1). Inhibition experiments revealed the predominance of [(123)I]IMT uptake via sodium-independent system L.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0969-8051
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
123-8
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11295422-Biological Transport,
pubmed-meshheading:11295422-Bone Neoplasms,
pubmed-meshheading:11295422-Humans,
pubmed-meshheading:11295422-Iodine Radioisotopes,
pubmed-meshheading:11295422-Kinetics,
pubmed-meshheading:11295422-Methyltyrosines,
pubmed-meshheading:11295422-Sarcoma, Ewing,
pubmed-meshheading:11295422-Tumor Cells, Cultured
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Characterization of 3-[123I]iodo-L-alpha-methyl tyrosine ([123I]IMT) transport into human Ewing's sarcoma cells in vitro.
|
| pubmed:affiliation |
Department of Nuclear Medicine, Westfälische Wilhelms-Universität, Münster, Albert-Schweitzer-Str. 33, 48149, Münster, Germany. franziu@uni-muenster.de
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| pubmed:publicationType |
Journal Article
|