Linked Life Data

11294746

Source:http://linkedlifedata.com/resource/pubmed/id/11294746

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-4-11
pubmed:abstractText
This experiment tested the hypothesis that running-induced damage to rat skeletal muscle causes changes in synthesis and degradation of basement membrane type IV collagen and to proteins regulating its degradation. Samples from soleus muscle and red and white parts of quadriceps femoris muscle (MQF) were collected 6 h or 1, 2, 4, or 7 days after downhill running. Increased muscle beta-glucuronidase activity indicated greater muscle damage in the red part of MQF than in the white part of MQF or soleus. In the red part of MQF, type IV collagen expression was upregulated at the pretranslational level and the protein concentration decreased, whereas matrix metalloproteinase-2 (MMP-2), a protein that degrades type IV collagen, and tissue inhibitor of metalloproteinase-2 (TIMP-2), a protein that inhibits degradation, were increased in parallel both at mRNA and protein levels. Type IV collagen mRNA level increased in the white part of MQF and soleus muscle. The protein concentration increased in the white part of MQF and was unchanged in soleus muscle. MMP-2 and TIMP-2 changed only slightly in the white part of MQF and soleus muscle. The changes seem to depend on the severity of myofiber injury and thus probably reflect reorganization of basement membrane compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
280
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1292-300
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11294746-Animals, pubmed-meshheading:11294746-Collagen, pubmed-meshheading:11294746-Female, pubmed-meshheading:11294746-Gene Expression Regulation, pubmed-meshheading:11294746-Glucuronidase, pubmed-meshheading:11294746-Matrix Metalloproteinase 2, pubmed-meshheading:11294746-Matrix Metalloproteinase 9, pubmed-meshheading:11294746-Muscle, Skeletal, pubmed-meshheading:11294746-Muscle Fibers, Fast-Twitch, pubmed-meshheading:11294746-Physical Exertion, pubmed-meshheading:11294746-Protein Biosynthesis, pubmed-meshheading:11294746-RNA, Messenger, pubmed-meshheading:11294746-Rats, pubmed-meshheading:11294746-Rats, Wistar, pubmed-meshheading:11294746-Running, pubmed-meshheading:11294746-Time Factors, pubmed-meshheading:11294746-Tissue Inhibitor of Metalloproteinase-1, pubmed-meshheading:11294746-Tissue Inhibitor of Metalloproteinase-2, pubmed-meshheading:11294746-Transcription, Genetic
pubmed:year
2001
pubmed:articleTitle
Acute exercise induced changes in rat skeletal muscle mRNAs and proteins regulating type IV collagen content.
pubmed:affiliation
Neuromuscular Research Center, Department of Biology of Physical Activity, University of Jyväskylä, 40351 Jyväskylä, Finland. koskinen@maila.jyu..fi
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't