|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2001-4-10
|
|
pubmed:abstractText |
The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino-1,3-thiazolyl]-thiophene-2-carboxamidines is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:BoneRR,
pubmed-author:DesJarlaisR LRL,
pubmed-author:GrasbergerBB,
pubmed-author:GreenDD,
pubmed-author:HoffmanJ BJB,
pubmed-author:IlligC RCR,
pubmed-author:LewandowskiF AFA,
pubmed-author:MaguireDD,
pubmed-author:MolloyC JCJ,
pubmed-author:RandallTT,
pubmed-author:RudolphM JMJ,
pubmed-author:SharpCC,
pubmed-author:SollRR,
pubmed-author:SpurlinoJJ,
pubmed-author:SubasingheNN,
pubmed-author:WilsonK JKJ,
pubmed-author:ZhangMM,
pubmed-author:ZhouZZ
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
9
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
915-8
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors.
|
|
pubmed:affiliation |
3-Dimensional Pharmaceuticals, Inc., Exton, PA 19341, USA. wilson@3dp.com
|
|
pubmed:publicationType |
Journal Article
|
