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rdf:type |
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lifeskim:mentions |
umls-concept:C0027950,
umls-concept:C0086418,
umls-concept:C0178719,
umls-concept:C0205531,
umls-concept:C0226896,
umls-concept:C0442027,
umls-concept:C0935763,
umls-concept:C1527148,
umls-concept:C1527415,
umls-concept:C1880355,
umls-concept:C1999216,
umls-concept:C2926735
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pubmed:issue |
7
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pubmed:dateCreated |
2001-4-10
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pubmed:databankReference |
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pubmed:abstractText |
The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AmourAA,
pubmed-author:ClarkeG DGD,
pubmed-author:DixonMM,
pubmed-author:DowleM DMD,
pubmed-author:FinchHH,
pubmed-author:FleetwoodGG,
pubmed-author:GodwardR ERE,
pubmed-author:HardyG WGW,
pubmed-author:HarrisonL ALA,
pubmed-author:HodgsonS TST,
pubmed-author:HumphreysDD,
pubmed-author:InglisG GGG,
pubmed-author:JohnsonM RMR,
pubmed-author:KumarK AKA,
pubmed-author:MacdonaldS JSJ,
pubmed-author:MolloyC RCR,
pubmed-author:MurkittGG,
pubmed-author:PadfieldTT,
pubmed-author:ShahPP,
pubmed-author:SinghO MOM,
pubmed-author:SkarzynskiTT,
pubmed-author:SmithR ARA
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
11
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
895-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11294386-Administration, Oral,
pubmed-meshheading:11294386-Animals,
pubmed-meshheading:11294386-Bacteria,
pubmed-meshheading:11294386-Bacterial Infections,
pubmed-meshheading:11294386-Biological Availability,
pubmed-meshheading:11294386-Cricetinae,
pubmed-meshheading:11294386-Crystallization,
pubmed-meshheading:11294386-Dogs,
pubmed-meshheading:11294386-Drug Stability,
pubmed-meshheading:11294386-Lactams,
pubmed-meshheading:11294386-Leukocyte Elastase,
pubmed-meshheading:11294386-Metabolic Clearance Rate,
pubmed-meshheading:11294386-Pancreatic Elastase,
pubmed-meshheading:11294386-Piperidines,
pubmed-meshheading:11294386-Rats,
pubmed-meshheading:11294386-Serine Endopeptidases,
pubmed-meshheading:11294386-Serpins
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pubmed:year |
2001
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pubmed:articleTitle |
The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate.
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pubmed:affiliation |
Medicinal Chemistry 2, GlaxoWellcome Medicines Research Centre, Stevenage, UK. sjfm5947@glaxowellcome.co.uk
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pubmed:publicationType |
Journal Article
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