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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-4-10
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pubmed:abstractText |
Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BarrK JKJ,
pubmed-author:CredoR BRB,
pubmed-author:FrostDD,
pubmed-author:GehrkeLL,
pubmed-author:GwaltneyS LSL2nd,
pubmed-author:ImadeH MHM,
pubmed-author:KovarPP,
pubmed-author:LUEE,
pubmed-author:LeeJ YJY,
pubmed-author:NgS CSC,
pubmed-author:NukkalaM AMA,
pubmed-author:ShamH LHL,
pubmed-author:WangJJ,
pubmed-author:WarnerR BRB,
pubmed-author:ZielinskiN ANA
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
871-4
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:11294380-Antineoplastic Agents,
pubmed-meshheading:11294380-Binding, Competitive,
pubmed-meshheading:11294380-Binding Sites,
pubmed-meshheading:11294380-Cell Division,
pubmed-meshheading:11294380-Colchicine,
pubmed-meshheading:11294380-Humans,
pubmed-meshheading:11294380-P-Glycoprotein,
pubmed-meshheading:11294380-Polymers,
pubmed-meshheading:11294380-Stilbenes,
pubmed-meshheading:11294380-Tubulin,
pubmed-meshheading:11294380-Tubulin Modulators,
pubmed-meshheading:11294380-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.
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pubmed:affiliation |
Cancer Research, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. stephen.gwaltney@abbott.com
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pubmed:publicationType |
Journal Article
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