| pubmed-article:11294245 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11294245 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:11294245 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:11294245 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:11294245 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:11294245 | lifeskim:mentions | umls-concept:C0288968 | lld:lifeskim |
| pubmed-article:11294245 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11294245 | pubmed:dateCreated | 2001-4-10 | lld:pubmed |
| pubmed-article:11294245 | pubmed:abstractText | Cysteine string protein (Csp) is a secretory vesicle protein previously demonstrated to be required for Ca2+-regulated exocytosis in neurons and endocrine cells. It has been suggested to function by regulating voltage-gated Ca2+ channels or, alternatively, to have a more direct effect on the regulated exocytotic machinery. Here we demonstrate the expression of Csp in mammary epithelial cells and in the KIM-2 mammary cell line. In KIM-2 cells, Csp was found to be associated with a population of small vesicles and showed partial co-distribution with the vesicle protein cellubrevin. KIM-2 cells do not express detectable levels of voltage-gated Ca2+ channels, ruling these out as a site of action. Using the release of transfected growth hormone (GH) as an assay of secretion, we found that GH is secreted in an exclusively constitutive manner from KIM-2 cells. Overexpression of Csp1 inhibits regulated exocytosis in other cell types but has no effect on constitutive GH release by KIM-2 cells. These results suggest that Csp does not have a major function in constitutive exocytosis. | lld:pubmed |
| pubmed-article:11294245 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11294245 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11294245 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11294245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11294245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11294245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11294245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11294245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11294245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11294245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11294245 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11294245 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11294245 | pubmed:issn | 0031-6768 | lld:pubmed |
| pubmed-article:11294245 | pubmed:author | pubmed-author:BeecheyR BRB | lld:pubmed |
| pubmed-article:11294245 | pubmed:author | pubmed-author:BurgoyneR DRD | lld:pubmed |
| pubmed-article:11294245 | pubmed:author | pubmed-author:GleaveT LTL | lld:pubmed |
| pubmed-article:11294245 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11294245 | pubmed:volume | 441 | lld:pubmed |
| pubmed-article:11294245 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11294245 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11294245 | pubmed:pagination | 639-49 | lld:pubmed |
| pubmed-article:11294245 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11294245 | pubmed:meshHeading | pubmed-meshheading:11294245... | lld:pubmed |
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| pubmed-article:11294245 | pubmed:meshHeading | pubmed-meshheading:11294245... | lld:pubmed |
| pubmed-article:11294245 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11294245 | pubmed:articleTitle | Cysteine string protein expression in mammary epithelial cells. | lld:pubmed |
| pubmed-article:11294245 | pubmed:affiliation | The Physiological Laboratory, University of Liverpool, UK. | lld:pubmed |
| pubmed-article:11294245 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11294245 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11294245 | lld:pubmed |
