Source:http://linkedlifedata.com/resource/pubmed/id/11293906
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2001-4-10
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| pubmed:abstractText |
We studied 20 cases of mature B-cell leukemia with more than 55% prolymphocytes in peripheral blood or bone marrow, fulfilling the French-American-British criteria for B-cell prolymphocytic leukemia (PLL). Cases segregated into 3 groups: de novo PLL, 6; PLL occurring in patients with a previous well-established diagnosis of chronic lymphocytic leukemia (PLL-HxCLL), 10; and t(11;14)(q13;q32)-positive neoplasms, 4. All cases expressed monotypic immunoglobulin light chain, and most were positive for CD5. All t(11;14)-positive neoplasms were CD23- and uniquely positive for cyclin D1. Cytogenetic abnormalities were present in 19; in all 19, the karyotype was complex, indicating clonal evolution and genomic instability. The most frequent cytogenetic abnormality in de novo PLL involved chromosome 7 in 4 cases. Trisomy 12 or add(12p) was present in 4 cases of PLL-HxCLL. We conclude that mature B-cell leukemias with more than 55% prolymphocytes are a heterogeneous group that includes t(11;14)-positive neoplasms, which we suggest are best classified as mantle cell lymphoma. We also suggest that prolymphocytic morphologic features are a common end-stage of transformation for several B-cell neoplasms.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0002-9173
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
115
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
571-81
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11293906-Aged,
pubmed-meshheading:11293906-Aged, 80 and over,
pubmed-meshheading:11293906-Antigens, CD5,
pubmed-meshheading:11293906-Bone Marrow Cells,
pubmed-meshheading:11293906-Cell Separation,
pubmed-meshheading:11293906-Chromosomes, Human, Pair 11,
pubmed-meshheading:11293906-Chromosomes, Human, Pair 13,
pubmed-meshheading:11293906-Chromosomes, Human, Pair 7,
pubmed-meshheading:11293906-Cyclin D1,
pubmed-meshheading:11293906-Female,
pubmed-meshheading:11293906-Flow Cytometry,
pubmed-meshheading:11293906-Humans,
pubmed-meshheading:11293906-Immunohistochemistry,
pubmed-meshheading:11293906-Leukemia, B-Cell,
pubmed-meshheading:11293906-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:11293906-Lymphocytes,
pubmed-meshheading:11293906-Lymphoma, Mantle-Cell,
pubmed-meshheading:11293906-Male,
pubmed-meshheading:11293906-Middle Aged,
pubmed-meshheading:11293906-Prognosis,
pubmed-meshheading:11293906-Receptors, IgE,
pubmed-meshheading:11293906-Trisomy
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| pubmed:year |
2001
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| pubmed:articleTitle |
Mature B-cell leukemias with more than 55% prolymphocytes. A heterogeneous group that includes an unusual variant of mantle cell lymphoma.
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| pubmed:affiliation |
Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, Houston, USA.
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| pubmed:publicationType |
Journal Article
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