Linked Life Data

11293255

Source:http://linkedlifedata.com/resource/pubmed/id/11293255

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-4-9
pubmed:abstractText
Performance of the Ludi (Insight II--MSI, ver. 98.0) program for computer-aided Ligand Design was tested using four crystallographic complexes of inhibitors with the HIV-1 protease. Possibility of reconstruction of the side chains and the peptide bond of the inhibitors, as well as attempt to construct de novo the central parts of these inhibitors, starting from the native structure of the enzyme, was studied. Results points that Ludi, although helpful, is merely initial tool for computer aided drug design. Moreover, some improvement of the program code is needed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0001-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
57 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Ligand design package (Ludi--MSI) applied to known inhibitors of the HIV-1 protease. Test of performance.
pubmed:affiliation
Interdisciplinary Centre of Mathematical & Computational Modelling, University of Warsaw, 5A Pawi?skiego Str., 02-106 Warsaw, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't