11293004

Source:http://linkedlifedata.com/resource/pubmed/id/11293004

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001613, umls-concept:C0032460, umls-concept:C0035820
pubmed:issue	1
pubmed:dateCreated	2001-4-9
pubmed:abstractText	Adrenal androgen excess affects approximately 25% of PCOS patients. The exact etiology of this excess in PCOS patients is unclear. Some evidence that adrenal androgen excess may be a genetic trait. The adrenal androgen response to ACTH is highly individualized, and the relative response seems to be constant over time. In addition, there is a strong familial component to adrenal androgen levels in normal individuals and PCOS patients. It is possible that the tendency to overproduce adrenal androgens is an inherited risk factor for the development of PCOS. Overall, few hyperandrogenic patients actually have isolated deficiencies of 3 beta-hydroxysteroid dehydrogenase, 21-hydroxylase, and 11-hydroxylase. The ovarian hormonal secretion in PCOS can affect adrenal androgen secretion and metabolism, although this factor accounts for only part of this abnormality. More likely, the adrenal androgen excess results from a generalized hyperresponsiveness of the adrenal cortex to ACTH, but without an increase in CRH or ACTH sensitivity. Although glucocorticoid administration may improve the ovulatory function of these patients, the results are modest and cannot be predicted by the circulating androgen levels.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8709551
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0889-8545
pubmed:author	pubmed-author:AzzizRR, pubmed-author:MoradMM
pubmed:issnType	Print
pubmed:volume	28
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	63-75
pubmed:dateRevised	2005-11-16
pubmed:meshHeading	pubmed-meshheading:11293004-Adrenal Cortex Diseases, pubmed-meshheading:11293004-Female, pubmed-meshheading:11293004-Humans, pubmed-meshheading:11293004-Polycystic Ovary Syndrome
pubmed:year	2001
pubmed:articleTitle	The role of the adrenal cortex in polycystic ovary syndrome.
pubmed:affiliation	Department of Obstetrics and Gynecology, Division of Reproductive Biology and Endocrinology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
pubmed:publicationType	Journal Article, Review