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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5515
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pubmed:dateCreated |
2001-4-16
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pubmed:abstractText |
The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans. We screened for long-lived mutants in nondividing yeast Saccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this life-span extension. These results indicate that longevity is associated with increased investment in maintenance and show that highly conserved genes play similar roles in life-span regulation in S. cerevisiae and higher eukaryotes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Transposable Elements,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MSN2 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/MSN4 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Paraquat,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Rim15 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/SCH9 protein kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
292
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
288-90
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11292860-Adenylate Cyclase,
pubmed-meshheading:11292860-Amino Acid Sequence,
pubmed-meshheading:11292860-Animals,
pubmed-meshheading:11292860-Caenorhabditis elegans,
pubmed-meshheading:11292860-Culture Media,
pubmed-meshheading:11292860-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:11292860-DNA Transposable Elements,
pubmed-meshheading:11292860-DNA-Binding Proteins,
pubmed-meshheading:11292860-Drosophila,
pubmed-meshheading:11292860-Drug Resistance, Microbial,
pubmed-meshheading:11292860-Gene Deletion,
pubmed-meshheading:11292860-Hot Temperature,
pubmed-meshheading:11292860-Longevity,
pubmed-meshheading:11292860-Molecular Sequence Data,
pubmed-meshheading:11292860-Mutagenesis, Insertional,
pubmed-meshheading:11292860-Oxidants,
pubmed-meshheading:11292860-Paraquat,
pubmed-meshheading:11292860-Phenotype,
pubmed-meshheading:11292860-Protein Kinases,
pubmed-meshheading:11292860-Saccharomyces cerevisiae,
pubmed-meshheading:11292860-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:11292860-Signal Transduction,
pubmed-meshheading:11292860-Transcription Factors,
pubmed-meshheading:11292860-Transformation, Genetic
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pubmed:year |
2001
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pubmed:articleTitle |
Regulation of longevity and stress resistance by Sch9 in yeast.
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pubmed:affiliation |
Division of Biogerontology, Andrus Gerontology Center, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-0191, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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