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rdf:type |
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lifeskim:mentions |
umls-concept:C0021745,
umls-concept:C0033268,
umls-concept:C0039194,
umls-concept:C0041296,
umls-concept:C0085358,
umls-concept:C0086418,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C1880177,
umls-concept:C2698600
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pubmed:issue |
5
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pubmed:dateCreated |
2001-4-9
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|
pubmed:abstractText |
The proportions of peripheral blood mononuclear cells (PBMC), CD4(+) T cells, and CD8(+) T cells that produce gamma interferon (IFN-gamma) in response to Mycobacterium tuberculosis were markedly reduced in tuberculosis patients, particularly in those with severe disease. Depletion of CD4(+) but not CD8(+) cells prior to stimulation of PBMC with M. tuberculosis abolished IFN-gamma production. These results show that (i) IFN-gamma production by CD8(+) and CD4(+) cells correlates with the clinical manifestations of M. tuberculosis infection and (ii) IFN-gamma production by CD8(+) cells depends on CD4(+) cells.
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pubmed:grant |
|
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-10075027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-10417164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-10496899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-10531205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-10558973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-10760288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-10861072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-6801178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-7622255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-7960152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-7989601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-8157267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-8778016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9180075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9187766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9200465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9206998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9314449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9419365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9423855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9453650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9584141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9624004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9756476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11292783-9893049
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0019-9567
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3497-501
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
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pubmed:year |
2001
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pubmed:articleTitle |
Contribution of CD8(+) T cells to gamma interferon production in human tuberculosis.
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|
pubmed:affiliation |
Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler 75708-3154, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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