Linked Life Data

11292496

Source:http://linkedlifedata.com/resource/pubmed/id/11292496

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-4-9
pubmed:abstractText
In the vertebrate brain excitatory synaptic contacts typically occur on the tiny evaginations of neuron dendritic surface known as dendritic spines. There is clear evidence that spine heads are endowed with voltage-dependent excitable channels and that action potentials invade spines. Computational models are being increasingly used to gain insight into the functional significance of a spine with an excitable membrane. The spike-diffuse-spike (SDS) model is one such model that admits to a relatively straightforward mathematical analysis. In this paper we demonstrate that not only can the SDS model support solitary travelling pulses, already observed numerically in more detailed biophysical models, but that it has periodic travelling wave solutions. The exact mathematical treatment of periodic travelling waves in the SDS model is used, within a kinematic framework, to predict the existence of connections between two periodic spike trains of different interspike interval. The associated wave front in the sequence of interspike intervals travels with a constant velocity without degradation of shape, and might therefore be used for the robust encoding of information.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0025-5564
pubmed:author
pubmed:issnType
Print
pubmed:volume
170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-72
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
From periodic travelling waves to travelling fronts in the spike-diffuse-spike model of dendritic waves.
pubmed:affiliation
Nonlinear and Complex Systems Group, Department of Mathematical Sciences, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK. s.coombes@lboro.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't