Linked Life Data

11292463

Source:http://linkedlifedata.com/resource/pubmed/id/11292463

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-4-9
pubmed:abstractText
There is evidence of similarities and interactions between central opioid and cannabinoid system with reference to drug reinforcement and abuse. Here we demonstrate that repeated injection of heroin produces behavioral sensitization towards administration of the synthetic cannabinoid receptor agonist WIN55212.2 in the rat. These effects were blocked by both the cannabinoid antagonist SR141716A and the opioid antagonist naloxone. These findings suggest that repeated exposure to heroin produces neuroadaptative changes in brain circuits that contribute to mediate the behavioral consequences of acute administration of WIN55212.2. The present results expand our knowledge on the interactions between central opioid and cannabinoid systems with respect to drug abuse.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
898
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
178-80
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Behavioral sensitization to WIN55212.2 in rats pretreated with heroin.
pubmed:affiliation
Department of Neuroscience, University La Sapienza, Viale dell'Università, 30 (box # 41), 00185, Rome, Italy. franceso.pontieri@uniroma1.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't