Linked Life Data

11291049

Source:http://linkedlifedata.com/resource/pubmed/id/11291049

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-4-6
pubmed:abstractText
Breast cancer is the most frequent malignancy among women. Since genetic factors such as BRCA1 and BRCA2 as well as reproductive history constitute only 30% of the cause, environmental exposure may play a significant role in the development of breast cancer. Likewise, the relevant enzymes involved in the biotransformation of xenobiotics (from tobacco smoke, diet or other environmental sources) might play a role in breast carcinogenesis. Since individuals with modified ability to metabolize these carcinogens could have a different risk for breast cancer, we investigated the role of cytochromes P-450 (CYP1A1, CYP2D6), glutathione-S-transferases (GSTM1, GSTT1, GSTP1) and N-acetyltransferases (NAT1, NAT2) gene variants in breast carcinogenesis. A case-control study was conducted on 149 women with breast carcinoma and 207 healthy controls, both of French-Canadian origin. The CYP1A1*4 allele was found to be a significant risk determinant of breast carcinoma (OR = 3.3, 95% CI 1.1-9.7), particularly among post-menopausal women (OR = 4.0, 95% CI 1.2-13.8). The frequency of NAT2 rapid acetylators was increased among smokers (OR = 2.6, 95% CI 0.8-8.2), while the NAT1*10 allele conferred a 4-fold increase in risk among women who consumed well-done meat (OR = 4.4, 95% CI 1.0-18.9). These data suggest that CYP1A1*4, NAT1 and NAT2 variants are involved in the susceptibility to breast carcinoma by modifying the impact of exogenous and/or endogenous exposures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0020-7136
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
220-5
pubmed:dateRevised
2010-9-8
pubmed:meshHeading
pubmed-meshheading:11291049-Arylamine N-Acetyltransferase, pubmed-meshheading:11291049-Breast Neoplasms, pubmed-meshheading:11291049-Canada, pubmed-meshheading:11291049-Carcinogens, pubmed-meshheading:11291049-Carcinoma, pubmed-meshheading:11291049-Case-Control Studies, pubmed-meshheading:11291049-Cytochrome P-450 CYP1A1, pubmed-meshheading:11291049-Cytochrome P-450 CYP2D6, pubmed-meshheading:11291049-Environmental Exposure, pubmed-meshheading:11291049-Female, pubmed-meshheading:11291049-France, pubmed-meshheading:11291049-Gene Frequency, pubmed-meshheading:11291049-Genetic Predisposition to Disease, pubmed-meshheading:11291049-Genotype, pubmed-meshheading:11291049-Glutathione Transferase, pubmed-meshheading:11291049-Humans, pubmed-meshheading:11291049-Isoenzymes, pubmed-meshheading:11291049-Menopause, pubmed-meshheading:11291049-Middle Aged, pubmed-meshheading:11291049-Polymorphism, Genetic, pubmed-meshheading:11291049-Risk Factors
pubmed:year
2001
pubmed:articleTitle
Genetic susceptibility to breast cancer in French-Canadians: role of carcinogen-metabolizing enzymes and gene-environment interactions.
pubmed:affiliation
Division of Hemato-Oncology, Charles-Bruneau Cancer Center, Sainte-Justine Hospital, University of Montreal, 3175 Côte Sainte Catherine, Montreal, Canada H3T 1C5.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't