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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0031272,
umls-concept:C0085358,
umls-concept:C0542341,
umls-concept:C1136310,
umls-concept:C1332717,
umls-concept:C1366562,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C1710548,
umls-concept:C2003941,
umls-concept:C2698600
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pubmed:issue |
8
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pubmed:dateCreated |
2001-4-6
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pubmed:abstractText |
We have recently demonstrated the presence of three populations of dendritic cells (DC) in the murine Peyer's patch. CD11b(+)/CD8alpha(-) (myeloid) DCs are localized in the subepithelial dome, CD11b(-)/CD8alpha(+) (lymphoid) DCs in the interfollicular regions, and CD11b(-)/CD8alpha(-) (double-negative; DN) DCs at both sites. We now describe the presence of a novel population of intraepithelial DN DCs within the follicle-associated epithelium and demonstrate a predominance of DN DCs only in mucosal lymphoid tissues. Furthermore, we demonstrate that all DC subpopulations maintain their surface phenotype upon maturation in vitro, and secrete a distinct pattern of cytokines upon exposure to T cell and microbial stimuli. Only myeloid DCs from the PP produce high levels of IL-10 upon stimulation with soluble CD40 ligand(-) trimer, or Staphylococcus aureus and IFN-gamma. In contrast, lymphoid and DN, but not myeloid DCs, produce IL-12p70 following microbial stimulation, whereas no DC subset produces IL-12p70 in response to CD40 ligand trimer. Finally, we show that myeloid DCs from the PP are particularly capable of priming naive T cells to secrete high levels of IL-4 and IL-10, when compared with those from nonmucosal sites, while lymphoid and DN DCs from all tissues prime for IFN-gamma production. These findings thus suggest that DC subsets within mucosal tissues have unique immune inductive capacities.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DEC-205 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage-1 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
166
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4884-90
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11290765-Animals,
pubmed-meshheading:11290765-Antigens, CD,
pubmed-meshheading:11290765-Antigens, CD8,
pubmed-meshheading:11290765-Antigens, CD80,
pubmed-meshheading:11290765-Antigens, CD86,
pubmed-meshheading:11290765-Cell Lineage,
pubmed-meshheading:11290765-Cell Separation,
pubmed-meshheading:11290765-Dendritic Cells,
pubmed-meshheading:11290765-Epithelial Cells,
pubmed-meshheading:11290765-Epitopes, T-Lymphocyte,
pubmed-meshheading:11290765-Female,
pubmed-meshheading:11290765-Histocompatibility Antigens Class II,
pubmed-meshheading:11290765-Immunophenotyping,
pubmed-meshheading:11290765-Interferon-gamma,
pubmed-meshheading:11290765-Interleukin-10,
pubmed-meshheading:11290765-Interleukin-12,
pubmed-meshheading:11290765-Interleukin-4,
pubmed-meshheading:11290765-Lectins, C-Type,
pubmed-meshheading:11290765-Lymphocyte Activation,
pubmed-meshheading:11290765-Lymphocyte Subsets,
pubmed-meshheading:11290765-Macrophage-1 Antigen,
pubmed-meshheading:11290765-Membrane Glycoproteins,
pubmed-meshheading:11290765-Mice,
pubmed-meshheading:11290765-Mice, Inbred BALB C,
pubmed-meshheading:11290765-Mice, Inbred C57BL,
pubmed-meshheading:11290765-Mice, Transgenic,
pubmed-meshheading:11290765-Myeloid Cells,
pubmed-meshheading:11290765-Peyer's Patches,
pubmed-meshheading:11290765-Receptors, Cell Surface,
pubmed-meshheading:11290765-Spleen,
pubmed-meshheading:11290765-T-Lymphocytes,
pubmed-meshheading:11290765-Up-Regulation
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pubmed:year |
2001
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pubmed:articleTitle |
Unique functions of CD11b+, CD8 alpha+, and double-negative Peyer's patch dendritic cells.
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pubmed:affiliation |
Immune Cell Interaction Unit, Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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