| pubmed-article:11290598 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11290598 | lifeskim:mentions | umls-concept:C1335875 | lld:lifeskim |
| pubmed-article:11290598 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:11290598 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:11290598 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11290598 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:11290598 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11290598 | pubmed:dateCreated | 2001-4-6 | lld:pubmed |
| pubmed-article:11290598 | pubmed:abstractText | We have previously shown that CD4(+) T cell-mediated allergic inflammation is diminished in signal transducer and activator of transcription (Stat)5a-deficient (Stat5a(-/-)) mice. To determine whether Stat5a regulates T helper cell differentiation, we studied T helper (Th)1 and Th2 cell differentiation of Stat5a(-/-)CD4(+) T cells at single-cell levels. First, Th2 cell differentiation from antigen-stimulated splenocytes was significantly decreased in Stat5a(-/-) mice as compared with that in wild-type mice. Further, Th2 cell differentiation was also impaired in Stat5a(-/-) mice even when purified CD4(+) T cells were stimulated with anti-CD3 plus anti-CD28 antibodies in the presence of interleukin-4. Moreover, the retrovirus-mediated gene expression of Stat5a in Stat5a(-/-)CD4(+) T cells restored the Th2 cell differentiation at the similar levels to that in wild-type CD4(+) T cells. In addition, interleukin-4 normally phosphorylated Stat6 in CD4(+) T cells from Stat5a(-/-) mice. Second, the development of CD4(+)CD25(+) immunoregulatory T cells was impaired in Stat5a(-/-) mice, as indicated by a significant decrease in the number of CD4(+)CD25(+) T cells in Stat5a(-/-) mice. Furthermore, the depletion of CD4(+)CD25(+) T cells from wild-type splenocytes significantly decreased Th2 cell differentiation but increased Th1 cell differentiation, whereas the depletion of CD4(+)CD25(+) T cells from Stat5a(-/-) splenocytes had no significant effect on the Th1 and Th2 cell differentiation. Together, these results indicate that the intrinsic expression of Stat5a in CD4(+) T cells is required for Th2 cell differentiation and that Stat5a is involved in the development of CD4(+)CD25(+) immunoregulatory T cells that modulate T helper cell differentiation toward Th2 cells. | lld:pubmed |
| pubmed-article:11290598 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11290598 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11290598 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11290598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11290598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11290598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11290598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11290598 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11290598 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11290598 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:11290598 | pubmed:author | pubmed-author:NakajimaHH | lld:pubmed |
| pubmed-article:11290598 | pubmed:author | pubmed-author:SuzukiKK | lld:pubmed |
| pubmed-article:11290598 | pubmed:author | pubmed-author:SaitoYY | lld:pubmed |
| pubmed-article:11290598 | pubmed:author | pubmed-author:MoritaSS | lld:pubmed |
| pubmed-article:11290598 | pubmed:author | pubmed-author:HiroseKK | lld:pubmed |
| pubmed-article:11290598 | pubmed:author | pubmed-author:KitamuraTT | lld:pubmed |
| pubmed-article:11290598 | pubmed:author | pubmed-author:KatzDD | lld:pubmed |
| pubmed-article:11290598 | pubmed:author | pubmed-author:IwamotoII | lld:pubmed |
| pubmed-article:11290598 | pubmed:author | pubmed-author:SutoAA | lld:pubmed |
| pubmed-article:11290598 | pubmed:author | pubmed-author:Kagami SS | lld:pubmed |
| pubmed-article:11290598 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11290598 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11290598 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:11290598 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11290598 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11290598 | pubmed:pagination | 2358-65 | lld:pubmed |
| pubmed-article:11290598 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11290598 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11290598 | pubmed:articleTitle | Stat5a regulates T helper cell differentiation by several distinct mechanisms. | lld:pubmed |
| pubmed-article:11290598 | pubmed:affiliation | Department of Internal Medicine II, Chiba University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:11290598 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11290598 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11290598 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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