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rdf:type |
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lifeskim:mentions |
umls-concept:C0026900,
umls-concept:C0032854,
umls-concept:C0033325,
umls-concept:C0072473,
umls-concept:C0205210,
umls-concept:C0288331,
umls-concept:C0681842,
umls-concept:C1332397,
umls-concept:C1514559,
umls-concept:C1527249,
umls-concept:C1561558,
umls-concept:C2825141
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pubmed:issue |
4
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pubmed:dateCreated |
2001-4-6
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pubmed:abstractText |
The aim of this study was twofold: to assess the relationship between c-Myb and Bcl-x expression and to evaluate the prognostic significance of their expression in colorectal carcinoma (CRC) patients. Analysis of tumors from 91 CRC patients for expression of c-Myb and Bcl-x revealed a significant relationship between these two proteins. Kaplan-Meier's analysis showed an increased risk of relapse and death in patients whose tumor specimens displayed high c-Myb levels and Bcl-x positivity. Similar results were also observed excluding Dukes' D patients. Molecular analysis using three c-Myb-overexpressing LoVo clones indicated that c-Myb overexpression was accompanied by up-regulation of Bcl-x(L) protein and mRNA. Tumors originating from these clones injected in nude mice were significantly larger than those formed in mice injected with parental or vector-transfected LoVo cells. Moreover, tumors derived from parental and control vector-transfected but not from c-Myb-overexpressing LoVo cells showed high frequency of apoptotic cells. These results provide direct evidence of an association between c-Myb and Bcl-x expression and suggest that expression of both molecules might be a useful prognostic marker in CRC.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-10213483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-10523863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-10567896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-1445802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-1709592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-2032228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-2103509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-2188735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-2194567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-2549488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-3652034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-7503659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-7741726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-7750937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-7812951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-8069852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-8123467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-8139540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-8276207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-8408047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-8625322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-8787680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-8804306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-8809414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-8946913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-8946914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9014855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9096387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9106689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9118748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9179053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9337147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9368661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9443406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9667660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9815900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9823328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11290547-9881495
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0002-9440
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pubmed:author |
pubmed-author:BenassiBB,
pubmed-author:BiroccioAA,
pubmed-author:BuglioniSS,
pubmed-author:CalabrettaBB,
pubmed-author:CitroGG,
pubmed-author:CosimelliMM,
pubmed-author:D'AgnanoII,
pubmed-author:D'AngeloCC,
pubmed-author:MottoleseMM,
pubmed-author:RamsayR GRG,
pubmed-author:RicciottiAA,
pubmed-author:ZupiGG
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pubmed:issnType |
Print
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1289-99
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11290547-Carcinoma,
pubmed-meshheading:11290547-Cell Division,
pubmed-meshheading:11290547-Colonic Neoplasms,
pubmed-meshheading:11290547-Humans,
pubmed-meshheading:11290547-Prognosis,
pubmed-meshheading:11290547-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:11290547-Proto-Oncogene Proteins c-myb,
pubmed-meshheading:11290547-RNA, Messenger,
pubmed-meshheading:11290547-Rectal Neoplasms,
pubmed-meshheading:11290547-Survival Analysis,
pubmed-meshheading:11290547-Transfection,
pubmed-meshheading:11290547-bcl-X Protein
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pubmed:year |
2001
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pubmed:articleTitle |
c-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer: clinical and experimental findings.
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pubmed:affiliation |
Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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