Linked Life Data

11290325

Source:http://linkedlifedata.com/resource/pubmed/id/11290325

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2001-4-6
pubmed:abstractText
Fgfs direct embryogenesis of several organs, including the lung, limb, and anterior pituitary. Here we report male-to-female sex reversal in mice lacking Fibroblast growth factor 9 (Fgf9), demonstrating a novel role for FGF signaling in testicular embryogenesis. Fgf9(-/-) mice also exhibit lung hypoplasia and die at birth. Reproductive system phenotypes range from testicular hypoplasia to complete sex reversal, with most Fgf9(-/-) XY reproductive systems appearing grossly female at birth. Fgf9 appears to act downstream of Sry to stimulate mesenchymal proliferation, mesonephric cell migration, and Sertoli cell differentiation in the embryonic testis. While Sry is found only in some mammals, Fgfs are highly conserved. Thus, Fgfs may function in sex determination and reproductive system development in many species.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
875-89
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11290325-Animals, pubmed-meshheading:11290325-Disorders of Sex Development, pubmed-meshheading:11290325-Embryonic and Fetal Development, pubmed-meshheading:11290325-Female, pubmed-meshheading:11290325-Fibroblast Growth Factor 9, pubmed-meshheading:11290325-Fibroblast Growth Factors, pubmed-meshheading:11290325-Genitalia, Female, pubmed-meshheading:11290325-Genitalia, Male, pubmed-meshheading:11290325-High Mobility Group Proteins, pubmed-meshheading:11290325-Male, pubmed-meshheading:11290325-Mice, pubmed-meshheading:11290325-Mice, Knockout, pubmed-meshheading:11290325-Ovary, pubmed-meshheading:11290325-Restriction Mapping, pubmed-meshheading:11290325-SOX9 Transcription Factor, pubmed-meshheading:11290325-Sex Differentiation, pubmed-meshheading:11290325-Testis, pubmed-meshheading:11290325-Transcription Factors
pubmed:year
2001
pubmed:articleTitle
Male-to-female sex reversal in mice lacking fibroblast growth factor 9.
pubmed:affiliation
Department of Molecular Biology and, Pharmacology, Washington University Medical School, Campus Box 8103, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't