Linked Life Data

11289129

Source:http://linkedlifedata.com/resource/pubmed/id/11289129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2001-4-5
pubmed:abstractText
Menopausal hormone replacement therapy has been widely used to alleviate the symptoms of menopause and to decrease the detrimental effects of ovarian hormone loss on bone density and cardiovascular health. Multiple studies of colorectal cancer epidemiology also support a role for hormone replacement therapy in prevention of colorectal cancer. We studied the effect of ovariectomy and estrogen replacement on tumor formation in C57BL/6J-Min/+ (Min/+) mice, animals that bear a germline mutation in murine Apc. These mice develop multiple intestinal tumors that show loss of wild-type Apc protein. After ovariectomy, intestinal adenomas in Min/+ mice increased by 77% (P = 0.0004). Ovariectomized Min/+ mice that were treated with a replacement dose of 17beta-estradiol had the same number of tumors as Min/+ mice that were neither castrated nor treated with estrogen replacement (P = 0.85). Examination of estrogen receptor (ER) levels in intestinal tissue by immunoblot showed changes in relative expression levels of ERalpha and ERbeta, with highest ERalpha and lowest ERbeta expression in the normal-appearing intestine of Min/+ mice, and lowest ERalpha and highest ERbeta expression in the enterocytes of animals that received 17beta-estradiol. These results suggest that endogenous estrogens protect against Apc-associated tumor formation and that tumor prevention by 17beta-estradiol is associated with an increase in ERbeta and a decrease in ERalpha expression in the target tissue.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2547-51
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11289129-Adenomatous Polyposis Coli Protein, pubmed-meshheading:11289129-Animals, pubmed-meshheading:11289129-Cytoskeletal Proteins, pubmed-meshheading:11289129-Enterocytes, pubmed-meshheading:11289129-Estradiol, pubmed-meshheading:11289129-Estrogen Receptor alpha, pubmed-meshheading:11289129-Estrogen Receptor beta, pubmed-meshheading:11289129-Estrogen Replacement Therapy, pubmed-meshheading:11289129-Estrogens, pubmed-meshheading:11289129-Female, pubmed-meshheading:11289129-Genes, APC, pubmed-meshheading:11289129-Germ-Line Mutation, pubmed-meshheading:11289129-Intestinal Neoplasms, pubmed-meshheading:11289129-Intestines, pubmed-meshheading:11289129-Mice, pubmed-meshheading:11289129-Mice, Inbred C57BL, pubmed-meshheading:11289129-Ovariectomy, pubmed-meshheading:11289129-Receptors, Estrogen
pubmed:year
2001
pubmed:articleTitle
Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis.
pubmed:affiliation
Department of Surgery and Pathology, Weill College of Medicine of Cornell University, New York, New York, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't