Linked Life Data

11288094

Source:http://linkedlifedata.com/resource/pubmed/id/11288094

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-4-5
pubmed:abstractText
Natural joints have an excellent lubricating function, but the detailed mechanism is still unclear. To clarify this lubricating mechanism, we observed the behavior of the cartilage surface under the physiological loading condition with confocal laser scanning microscopy in normal and osteoarthritis (OA) cartilage rabbit specimens. Even with a considerable loading condition, in both natural and OA cartilage, the fluid pool area coexisted with the direct contact area. In the junction from the direct contact area to the fluid area, there was a third area with a liquid-crystal arrangement. In OA cartilage, these areas were generally irregular and small. These results suggest that a lubrication system in the fluid phase, such as squeeze film lubrication, might work under severe pressure in normal cartilage, and hyaluronic acid macromolecules in the synovial fluid might form a liquid-crystal structure and support pressure on the cartilage surface, whereas these systems did not affect the OA cartilage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-9304
pubmed:author
pubmed:copyrightInfo
Copyright 2001 John Wiley & Sons, Inc. J Biomed Mater Res 55: 645-651, 2001
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
645-51
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Study on the lubrication mechanism of natural joints by confocal laser scanning microscopy.
pubmed:affiliation
Department of Tissue Regeneration, Institute for Frontier Medical Science, Kyoto University, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan.
pubmed:publicationType
Journal Article