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rdf:type |
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lifeskim:mentions |
umls-concept:C0017278,
umls-concept:C0019704,
umls-concept:C0034494,
umls-concept:C0039195,
umls-concept:C0205263,
umls-concept:C0370215,
umls-concept:C0442335,
umls-concept:C0442821,
umls-concept:C0871261,
umls-concept:C1422036,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
9
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pubmed:dateCreated |
2001-4-5
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pubmed:abstractText |
Novel viral vectors that are able to induce both strong and long-lasting immune responses may be required as effective vaccines for human immunodeficiency virus type 1 (HIV-1) infection. Our previous experiments with a replication-competent vaccine strain-based rabies virus (RV) expressing HIV-1 envelope protein from a laboratory-adapted HIV-1 strain (NL4-3) and a primary HIV-1 isolate (89.6) showed that RV-based vectors are excellent for B-cell priming. Here we report that cytotoxic T-lymphocyte (CTL) responses against HIV-1 gp160 are induced by recombinant RVs. Our results indicated that a single inoculation of mice with an RV expressing HIV-1 gp160 induced a solid and long-lasting memory CTL response specific for HIV-1 envelope protein. Moreover, CTLs from immunized mice were not restricted to the homologous HIV-1 envelope protein and were able to cross-kill target cells expressing HIV-1 gp160 from heterologous HIV-1 strains. These studies further suggest promise for RV-based vectors to elicit a persistent immune response against HIV-1 and their potential utility as efficacious anti-HIV-1 vaccines.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10221533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10233923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10371502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10396782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10448136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10465068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10479171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10546852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10566149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10590126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10655111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10684290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10729127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-10885771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-11039923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-1372650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-1386410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-1470917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-1502197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-1715361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-2032289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-7635981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-7892606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-8068412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-8235045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-8627721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-9037064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-9188571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-9343219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-9390747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-9451974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-9462925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-9792840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-9802890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-9814958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-9854042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11287595-9930868
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4430-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11287595-Animals,
pubmed-meshheading:11287595-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11287595-Cross Reactions,
pubmed-meshheading:11287595-Cytotoxicity, Immunologic,
pubmed-meshheading:11287595-Female,
pubmed-meshheading:11287595-Genetic Vectors,
pubmed-meshheading:11287595-HIV Envelope Protein gp160,
pubmed-meshheading:11287595-HIV-1,
pubmed-meshheading:11287595-Humans,
pubmed-meshheading:11287595-Mice,
pubmed-meshheading:11287595-Mice, Inbred BALB C,
pubmed-meshheading:11287595-Rabies virus,
pubmed-meshheading:11287595-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11287595-Vaccination
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pubmed:year |
2001
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pubmed:articleTitle |
Rabies virus-based vectors expressing human immunodeficiency virus type 1 (HIV-1) envelope protein induce a strong, cross-reactive cytotoxic T-lymphocyte response against envelope proteins from different HIV-1 isolates.
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pubmed:affiliation |
The Dorrance H. Hamilton Laboratories, Center for Human Virology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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