Linked Life Data

11286999

Source:http://linkedlifedata.com/resource/pubmed/id/11286999

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2001-4-5
pubmed:abstractText
We recently demonstrated that the sphingomyelin (SM) content of adipocyte membranes was negatively correlated with the expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the subcutaneous adipose tissue of obese women with variable degrees of insulin resistance. We have now investigated whether SM really does have an impact on the expression of PPARgamma in 3T3-F442A adipocytes. Adding SM to the culture medium for 24 h caused a significant increase in SM content of adipocyte membranes and an acyl chain length-dependent decrease in the levels of PPARgamma mRNA and protein. The longer the acyl chain of the fatty acid of SM, the greater was the decrease in PPARgamma. These data suggest that the nature of the fatty acid is important in the regulation of PPARgamma by the SM pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
493
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Down-regulation of peroxisome proliferator-activated receptor-gamma gene expression by sphingomyelins.
pubmed:affiliation
Laboratoire de Nutrition et Maladdies Métaboliques, EA 2402, Proliferateurs de Peroxisomes, Faculté de Médecine, Université Henri-Poincaré, 54505 Vandoeuvre les Nancy, France. nehman.al-makdissy@nancy.inserm.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't