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rdf:type |
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lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0037733,
umls-concept:C0162835,
umls-concept:C0449445,
umls-concept:C1262902,
umls-concept:C1523987,
umls-concept:C1555707,
umls-concept:C1704259,
umls-concept:C1705851,
umls-concept:C1705987,
umls-concept:C2752151,
umls-concept:C2828366
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pubmed:issue |
4
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pubmed:dateCreated |
2001-4-5
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pubmed:abstractText |
The protease-activated receptor 2, expressed on keratinocytes but not on melanocytes, has been ascribed functional importance in the regulation of pigmentation by phagocytosis of melanosomes. Inhibition of protease-activated receptor 2 activation by synthetic serine protease inhibitors requires keratinocyte-melanocyte contact and results in depigmentation of the dark skinned Yucatan swine, suggesting a new class of depigmenting mechanism and agents. We therefore examined natural agents that could exert their effect via the protease-activated receptor 2 pathway. Here we show that soymilk and the soybean-derived serine protease inhibitors soybean trypsin inhibitor and Bowman-Birk inhibitor inhibit protease-activated receptor 2 cleavage, affect cytoskeletal and cell surface organization, and reduce keratinocyte phagocytosis. The depigmenting activity of these agents and their capability to prevent ultraviolet-induced pigmentation are demonstrated both in vitro and in vivo. These results imply that inhibition of the protease-activated receptor 2 pathway by soymilk may be used as a natural alternative to skin lightening.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-202X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
587-95
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11286627-Animals,
pubmed-meshheading:11286627-Beverages,
pubmed-meshheading:11286627-Cells, Cultured,
pubmed-meshheading:11286627-Humans,
pubmed-meshheading:11286627-Keratinocytes,
pubmed-meshheading:11286627-Mice,
pubmed-meshheading:11286627-Mice, SCID,
pubmed-meshheading:11286627-Phagocytosis,
pubmed-meshheading:11286627-Plant Extracts,
pubmed-meshheading:11286627-Plant Proteins,
pubmed-meshheading:11286627-Receptor, PAR-2,
pubmed-meshheading:11286627-Receptors, Thrombin,
pubmed-meshheading:11286627-Skin Pigmentation,
pubmed-meshheading:11286627-Soybeans,
pubmed-meshheading:11286627-Swine,
pubmed-meshheading:11286627-Trypsin Inhibitor, Bowman-Birk Soybean,
pubmed-meshheading:11286627-Trypsin Inhibitors,
pubmed-meshheading:11286627-alpha-Amylases
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pubmed:year |
2001
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pubmed:articleTitle |
An alternative approach to depigmentation by soybean extracts via inhibition of the PAR-2 pathway.
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pubmed:affiliation |
Johnson & Johnson-Consumer Products Worldwide, Skin Research Center, Skillman, New Jersey 08558, USA.
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pubmed:publicationType |
Journal Article
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