Linked Life Data

11285407

Source:http://linkedlifedata.com/resource/pubmed/id/11285407

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-4-4
pubmed:abstractText
Anetoderma is circumscribed atrophy of the skin due to a localized deficiency in elastic tissue. It can follow inflammatory skin diseases of several types, and occasionally is present in the skin around neoplasms. There are a few reports of anetoderma in the lesional skin of cutaneous lymphoma. We report on two patients who presented with multiple lesions of anetoderma and who later proved to have low-grade cutaneous B-cell lymphomas. One patient (Patient 1) is a 39-year-old man and the other patient is a 26-year-old woman who is a renal transplant recipient (Patient 2). Some biopsy specimens from the anetodermic skin of Patient 1 appeared to show an urticarial reaction, although plasma cells were present. A large nodule showed lymphoid follicles surrounded by plasmacytoid lymphocytes, with loss of elastic tissue in the adjacent dermis. The plasmacytoid cells stained overwhelmingly for lambda light chain, and staining of the urticarial lesions from this patient also showed a marked majority of lambda positive cells. Immunoglobulin heavy chain gene (IgH) rearrangements showed a dominant clonal pattern in the nodular lesion. We classified the disease in Patient 1 as marginal zone lymphoma and the disease in Patient 2 as a post-transplant lymphoproliferative disorder. Because of the intimate association of anetoderma and cutaneous B-cell lymphoproliferative disorders in these two patients, it seems possible that anetoderma could result from either a local effect of the neoplastic cells or associated inflammatory cells, especially neutrophils as in Case 1. The infiltrates of Case 1 had many interstitial neutrophils and only a few clonal plasmacytoid lymphocytes, indicating that this presentation of B-cell lymphoma can be a diagnostic pitfall. Given these two cases and similar ones in the literature, biopsy of lesional skin in anetoderma should be performed to ensure that lymphomatous infiltrates are not present. Even if plasma cells are sparse, studies to detect clonality are appropriate. Cutaneous B-cell lymphoma can be added to the list of associations of elastolysis and cutaneous lymphoma, which includes granulomatous slack skin (T-cell lymphoma) and cutis laxa (myeloma).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0193-1091
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
124-32
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11285407-Adult, pubmed-meshheading:11285407-Atrophy, pubmed-meshheading:11285407-Cutis Laxa, pubmed-meshheading:11285407-Cyclosporine, pubmed-meshheading:11285407-DNA, pubmed-meshheading:11285407-Elastic Tissue, pubmed-meshheading:11285407-Female, pubmed-meshheading:11285407-Fluorescein-5-isothiocyanate, pubmed-meshheading:11285407-Gene Rearrangement, B-Lymphocyte, Heavy Chain, pubmed-meshheading:11285407-Herpesvirus 4, Human, pubmed-meshheading:11285407-Humans, pubmed-meshheading:11285407-Immunocompromised Host, pubmed-meshheading:11285407-Immunohistochemistry, pubmed-meshheading:11285407-In Situ Hybridization, pubmed-meshheading:11285407-Kidney Transplantation, pubmed-meshheading:11285407-Leukemia, Lymphocytic, Chronic, B-Cell, pubmed-meshheading:11285407-Lymphoma, B-Cell, pubmed-meshheading:11285407-Lymphoproliferative Disorders, pubmed-meshheading:11285407-Male, pubmed-meshheading:11285407-Polymerase Chain Reaction, pubmed-meshheading:11285407-RNA, Viral, pubmed-meshheading:11285407-Skin Neoplasms, pubmed-meshheading:11285407-Tacrolimus
pubmed:year
2001
pubmed:articleTitle
Anetoderma arising in cutaneous B-cell lymphoproliferative disease.
pubmed:affiliation
Department of Pathology, University of California, San Francisco 94115, USA.
pubmed:publicationType
Journal Article, Case Reports