11284951

Source:http://linkedlifedata.com/resource/pubmed/id/11284951

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021344, umls-concept:C0032520, umls-concept:C0205225, umls-concept:C0237881, umls-concept:C0281187, umls-concept:C0750502, umls-concept:C1511790
pubmed:issue	2
pubmed:dateCreated	2001-4-4
pubmed:abstractText	The purposes of this study were to evaluate the incidence of high-risk human papillomavirus (HPV) infection by polymerase chain reaction (PCR) and to assess its diagnostic usefulness in primary cervical screening. PCR testing for HPV type 16, 18, 31 and 33 was performed on 1305 specimens obtained during routine cervical cancer screening. We analysed the concurrent cervical smears and biopsy, and correlated them with the HPV infection status. We also evaluated histologically-proven cases with ASCUS smears according to HPV infection. HPV DNA was identified in eight (0.7%) of 1144 cytologically normal patients; nine (10.5%) of 86 ASCUS; seven (25.0%) of 28 LSIL; 26 (78.8%) of 33 HSIL; and in all of three squamous cell carcinomas (SCC). HPV positivity was significantly associated with cytohistological diagnosis for HSIL of more. In addition, HPV-positive ASCUS cases were found to be associated with histological abnormality rather than HPV-negative. The results indicate that high-risk HPV testing by PCR could be a useful adjunct tool for Pap smear in primary cervical screening. The combination of Pap smear and high-risk HPV testing by PCR might reduce unnecessary colposcopy-guided biopsy of women with cytological diagnosis of ASCUS.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/11284951-11284950
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9010345
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0956-5507
pubmed:author	pubmed-author:HanJJ, pubmed-author:KimD SDS, pubmed-author:ShinK JKJ, pubmed-author:YouCC
pubmed:issnType	Print
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	75-83
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:11284951-Adult, pubmed-meshheading:11284951-Age Distribution, pubmed-meshheading:11284951-Aged, pubmed-meshheading:11284951-Cervical Intraepithelial Neoplasia, pubmed-meshheading:11284951-DNA, Viral, pubmed-meshheading:11284951-False Negative Reactions, pubmed-meshheading:11284951-False Positive Reactions, pubmed-meshheading:11284951-Female, pubmed-meshheading:11284951-Humans, pubmed-meshheading:11284951-Korea, pubmed-meshheading:11284951-Mass Screening, pubmed-meshheading:11284951-Middle Aged, pubmed-meshheading:11284951-Papillomaviridae, pubmed-meshheading:11284951-Polymerase Chain Reaction, pubmed-meshheading:11284951-Predictive Value of Tests, pubmed-meshheading:11284951-Risk, pubmed-meshheading:11284951-Sensitivity and Specificity, pubmed-meshheading:11284951-Uterine Cervical Diseases, pubmed-meshheading:11284951-Uterine Cervical Neoplasms, pubmed-meshheading:11284951-Vaginal Smears
pubmed:year	2001
pubmed:articleTitle	Significance of high-risk human papillomavirus detection by polymerase chain reaction in primary cervical cancer screening.
pubmed:affiliation	Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-ku, Seoul, Korea.
pubmed:publicationType	Journal Article, Comparative Study, Evaluation Studies