Source:http://linkedlifedata.com/resource/pubmed/id/11284442
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2001-4-3
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pubmed:abstractText |
The interaction between an inhibitor of angiotensin I converting enzyme (ramipril) and renal lithium handling was analysed in conscious, normotensive Wistar rats in the absence or the presence of a specific bradykinin B2 receptor antagonist, icatibant. The rats were treated for 5 days with ramipril (1 mg/kg/day p.o.) or its vehicle, alone or together with icatibant (0.1 mg/kg/day, s.c. infusion). Lithium chloride (8.3 mg/kg i.p.) was given as a single dose on day 5. Systolic blood pressure and heart rate were measured by tail plethysmography on day 3 (3, 9 and 15 h after ramipril administration) and renal function on day 4 (0-6 and 6-24 h urine sampling) and day 5 (0-6 h urine sampling). In another group of rats, 24 h sodium excretion was assessed during the first 4 days of ramipril treatment. Ramipril decreased renal lithium clearance (90+/-8 vs. 142+/-10 microl/min/100 g, P<0.001, n=24) and increased the fractional lithium reabsorption (74.3+/-1.9 vs. 66.7+/-1.7%, P<0.05) and plasma lithium concentration (0.108+/-0.006 vs. 0.085+/-0.004 mM, P<0.01). Alteration of renal lithium handling by ramipril was associated with a decrease in systolic blood pressure (-15% 3 h after ramipril administration) and sodium excretion (0-6 h after ramipril). The 24-h sodium excretion, however, tended to increase. Icatibant had no effect per se on renal function but attenuated the ramipril-induced decrease in renal lithium clearance (118+/-16 vs. 90+/-8 microl/min/100 g, n=12 and 24 respectively, P<0.05 one-tailed test) and systolic blood pressure. These results suggest that endogenous bradykinin contributes to the ramipril-associated alteration in renal lithium handling. Bradykinin B2 receptor-mediated vasodilation seems to be involved.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Ramipril,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Bradykinin B2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/icatibant
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0028-1298
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
363
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-7
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:11284442-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:11284442-Animals,
pubmed-meshheading:11284442-Blood Pressure,
pubmed-meshheading:11284442-Bradykinin,
pubmed-meshheading:11284442-Depression, Chemical,
pubmed-meshheading:11284442-Drug Interactions,
pubmed-meshheading:11284442-Kidney,
pubmed-meshheading:11284442-Lithium,
pubmed-meshheading:11284442-Lithium Chloride,
pubmed-meshheading:11284442-Male,
pubmed-meshheading:11284442-Ramipril,
pubmed-meshheading:11284442-Rats,
pubmed-meshheading:11284442-Rats, Wistar,
pubmed-meshheading:11284442-Receptor, Bradykinin B2,
pubmed-meshheading:11284442-Receptors, Bradykinin,
pubmed-meshheading:11284442-Sodium
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pubmed:year |
2001
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pubmed:articleTitle |
Effects of icatibant on the ramipril-induced decreased in renal lithium clearance in the rat.
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pubmed:affiliation |
Institut de Pharmacologie, Faculté de Médecine, Université Louis Pasteur, Strasbourg, France.
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pubmed:publicationType |
Journal Article
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