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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-4-4
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pubmed:abstractText |
The discovery of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminating acetylcholine-mediated neurotransmission made it the focus of intense research for much of the past century. But the complexity of acetylcholinesterase gene regulation and recent evidence for some of the long-suspected 'non-classical' actions of this enzyme have more recently driven a profound revolution in acetylcholinesterase research. Although our understanding of the additional roles of acetylcholinesterase is incomplete, the time is ripe to summarize the evidence on a remarkable diversity of acetylcholinesterase functions.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1471-003X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
294-302
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11283752-Acetylcholinesterase,
pubmed-meshheading:11283752-Alternative Splicing,
pubmed-meshheading:11283752-Animals,
pubmed-meshheading:11283752-Cell Adhesion,
pubmed-meshheading:11283752-Cholinesterase Inhibitors,
pubmed-meshheading:11283752-Dopamine,
pubmed-meshheading:11283752-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:11283752-Hematopoiesis,
pubmed-meshheading:11283752-Humans,
pubmed-meshheading:11283752-Multienzyme Complexes,
pubmed-meshheading:11283752-Mutation,
pubmed-meshheading:11283752-Neurodegenerative Diseases,
pubmed-meshheading:11283752-Neurons,
pubmed-meshheading:11283752-Persian Gulf Syndrome,
pubmed-meshheading:11283752-Phenotype,
pubmed-meshheading:11283752-Plaque, Amyloid,
pubmed-meshheading:11283752-Protein Transport,
pubmed-meshheading:11283752-Stress, Physiological,
pubmed-meshheading:11283752-Synapses
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pubmed:year |
2001
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pubmed:articleTitle |
Acetylcholinesterase--new roles for an old actor.
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pubmed:publicationType |
Editorial,
Review
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