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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-4-3
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pubmed:abstractText |
A mutation (CCG-->CTG [Arg-->Leu]) in codon 463 of katG (catalase peroxidase) of Mycobacterium tuberculosis has been found in isoniazid (INH)-resistant strains. A PCR restriction endonuclease analysis to detect this mutation was applied to 395 M. tuberculosis isolates from patients in The Netherlands. The proportion of isolates with a detectable mutation was 32% (32 out of 100) and 29% (85 out of 295) among INH-susceptible isolates and INH-resistant or -intermediate isolates, respectively. Sequencing of five INH-susceptible isolates with such mutations showed that all five had the Arg463Leu mutation. We conclude that the Arg463Leu mutation of katG of M. tuberculosis is not a reliable indicator of INH resistance.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-11069256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-14903503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-14924201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-1501713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-1509256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-2324277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-7637495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-7706824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-7746145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-7798673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-7890405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-7914261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-8284673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-8376822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-8381207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-8537659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-8542139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-8585728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-9142789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-9170012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-9210694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-9333184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-9432394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11283093-9534978
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1591-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11283093-Antitubercular Agents,
pubmed-meshheading:11283093-Arginine,
pubmed-meshheading:11283093-Bacterial Proteins,
pubmed-meshheading:11283093-Codon,
pubmed-meshheading:11283093-Drug Resistance, Microbial,
pubmed-meshheading:11283093-Humans,
pubmed-meshheading:11283093-Isoniazid,
pubmed-meshheading:11283093-Leucine,
pubmed-meshheading:11283093-Mutation,
pubmed-meshheading:11283093-Mycobacterium tuberculosis,
pubmed-meshheading:11283093-Netherlands,
pubmed-meshheading:11283093-Peroxidases,
pubmed-meshheading:11283093-Polymerase Chain Reaction,
pubmed-meshheading:11283093-Sequence Analysis, DNA,
pubmed-meshheading:11283093-Tuberculosis
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pubmed:year |
2001
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pubmed:articleTitle |
The susceptibility of Mycobacterium tuberculosis to isoniazid and the Arg-->Leu mutation at codon 463 of katG are not associated.
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pubmed:affiliation |
Academic Medical Center, Department of Medical Microbiology, Amsterdam, The Netherlands. h.r.vandoorn@amc.uva.nl
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pubmed:publicationType |
Journal Article
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