| pubmed-article:11282897 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11282897 | lifeskim:mentions | umls-concept:C0001483 | lld:lifeskim |
| pubmed-article:11282897 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:11282897 | lifeskim:mentions | umls-concept:C0388911 | lld:lifeskim |
| pubmed-article:11282897 | lifeskim:mentions | umls-concept:C1257789 | lld:lifeskim |
| pubmed-article:11282897 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11282897 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11282897 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11282897 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11282897 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11282897 | pubmed:dateCreated | 2001-4-3 | lld:pubmed |
| pubmed-article:11282897 | pubmed:abstractText | The growth of blood and lymphatic vasculature is mediated in part by secreted polypeptides of the vascular endothelial growth factor (VEGF) family. The prototype VEGF binds VEGF receptor (VEGFR)-1 and VEGFR-2 and is angiogenic, whereas VEGF-C, which binds to VEGFR-2 and VEGFR-3, is either angiogenic or lymphangiogenic in different assays. We used an adenoviral gene transfer approach to compare the effects of these growth factors in adult mice. Recombinant adenoviruses encoding human VEGF-C or VEGF were injected subcutaneously into C57Bl6 mice or into the ears of nude mice. Immunohistochemical analysis showed that VEGF-C upregulated VEGFR-2 and VEGFR-3 expression and VEGF upregulated VEGFR-2 expression at 4 days after injection. After 2 weeks, histochemical and immunohistochemical analysis, including staining for the lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), the vascular endothelial marker platelet-endothelial cell adhesion molecule-1 (PECAM-1), and the proliferating cell nuclear antigen (PCNA) revealed that VEGF-C induced mainly lymphangiogenesis in contrast to VEGF, which induced only angiogenesis. These results have significant implications in the planning of gene therapy using these growth factors. | lld:pubmed |
| pubmed-article:11282897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11282897 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11282897 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11282897 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11282897 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11282897 | pubmed:issn | 1524-4571 | lld:pubmed |
| pubmed-article:11282897 | pubmed:author | pubmed-author:KuboHH | lld:pubmed |
| pubmed-article:11282897 | pubmed:author | pubmed-author:StenbackFF | lld:pubmed |
| pubmed-article:11282897 | pubmed:author | pubmed-author:AlitaloKK | lld:pubmed |
| pubmed-article:11282897 | pubmed:author | pubmed-author:JacksonD GDG | lld:pubmed |
| pubmed-article:11282897 | pubmed:author | pubmed-author:Yla-Herttuala... | lld:pubmed |
| pubmed-article:11282897 | pubmed:author | pubmed-author:JeltschMM | lld:pubmed |
| pubmed-article:11282897 | pubmed:author | pubmed-author:EnholmBB | lld:pubmed |
| pubmed-article:11282897 | pubmed:author | pubmed-author:PrevoRR | lld:pubmed |
| pubmed-article:11282897 | pubmed:author | pubmed-author:KarpanenTT | lld:pubmed |
| pubmed-article:11282897 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:11282897 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:11282897 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:11282897 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11282897 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11282897 | pubmed:pagination | 623-9 | lld:pubmed |
| pubmed-article:11282897 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11282897 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11282897 | pubmed:articleTitle | Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin. | lld:pubmed |
| pubmed-article:11282897 | pubmed:affiliation | Molecular/Cancer Biology Laboratory and Ludvig Institute for Cancer Research, Haartman Institute, University of Helsinki, Finland. | lld:pubmed |
| pubmed-article:11282897 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11282897 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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