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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2001-5-23
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pubmed:abstractText |
Here we describe the cloning, localization, and characterization of a novel mammalian endo-apyrase (LALP1) in human and mouse. The predicted human LALP1 gene encodes a 604-amino acid protein, whereas the mouse Lalp1 gene encodes a 606-amino acid protein. The human and mouse genes have 88% amino acid sequence identity. These genes share considerable homologies with hLALP70, a recently discovered mammalian lysosomal endo-apyrase. The human LALP1 gene resides on chromosome 10q23-q24 and contains 12 exons and 11 introns covering a genomic region of approximately 46 kilobase pairs. The subcellular localization and enzymatic activity of LALP1 indicated that LALP1 is indeed an endo-apyrase with substrate preference for nucleoside triphosphates UTP, GTP, and CTP.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-9258
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pubmed:author |
pubmed-author:CruzP EPE,
pubmed-author:Davoodi-SemiromiAA,
pubmed-author:FOXJ NJN,
pubmed-author:KukarTT,
pubmed-author:LiQ ZQZ,
pubmed-author:LianWW,
pubmed-author:SheJ XJX,
pubmed-author:WangC YCY,
pubmed-author:WuD HDH,
pubmed-author:XiuF XFX,
pubmed-author:YangPP
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
276
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17474-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11278936-Amino Acid Sequence,
pubmed-meshheading:11278936-Animals,
pubmed-meshheading:11278936-Apyrase,
pubmed-meshheading:11278936-Base Sequence,
pubmed-meshheading:11278936-Cell Line,
pubmed-meshheading:11278936-Chromosome Mapping,
pubmed-meshheading:11278936-Chromosomes, Human, Pair 10,
pubmed-meshheading:11278936-Cloning, Molecular,
pubmed-meshheading:11278936-Cytidine Triphosphate,
pubmed-meshheading:11278936-Guanosine Triphosphate,
pubmed-meshheading:11278936-Humans,
pubmed-meshheading:11278936-Kinetics,
pubmed-meshheading:11278936-Male,
pubmed-meshheading:11278936-Mammals,
pubmed-meshheading:11278936-Mice,
pubmed-meshheading:11278936-Molecular Sequence Data,
pubmed-meshheading:11278936-Organ Specificity,
pubmed-meshheading:11278936-Pyrophosphatases,
pubmed-meshheading:11278936-Recombinant Proteins,
pubmed-meshheading:11278936-Sequence Alignment,
pubmed-meshheading:11278936-Sequence Homology, Amino Acid,
pubmed-meshheading:11278936-Substrate Specificity,
pubmed-meshheading:11278936-Transfection,
pubmed-meshheading:11278936-Uridine Triphosphate
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pubmed:year |
2001
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pubmed:articleTitle |
Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1).
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pubmed:affiliation |
Department of Pathology, Immunology and Laboratory Medicine, Center for Mammalian Genetics and Diabetes Center of Excellence, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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