|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
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|
pubmed:dateCreated |
2001-3-29
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|
pubmed:abstractText |
Computer-aided modelling has been used to identify a putative antagonist binding site in the tachykinin NK2 receptor. In order to validate the implied spatial requirements for this region, a series of compounds, based on the potent antagonist GR 149861 have been synthesised and their binding affinities established. Our findings suggest the presence of a large hydrophobic cavity in the putative binding crevice of GR 149861.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Mar
|
|
pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
819-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11277528-Binding Sites,
pubmed-meshheading:11277528-Indoles,
pubmed-meshheading:11277528-Methylurea Compounds,
pubmed-meshheading:11277528-Models, Molecular,
pubmed-meshheading:11277528-Molecular Conformation,
pubmed-meshheading:11277528-Morpholines,
pubmed-meshheading:11277528-Piperidines,
pubmed-meshheading:11277528-Protein Conformation,
pubmed-meshheading:11277528-Receptors, Neurokinin-2,
pubmed-meshheading:11277528-Structure-Activity Relationship
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
Spatial requirements of the antagonist binding site of the NK2 receptor.
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|
pubmed:affiliation |
School of Chemistry, University of Leeds, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
