Source:http://linkedlifedata.com/resource/pubmed/id/11277523
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2001-3-29
|
| pubmed:abstractText |
Sixteen novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds were synthesized using substituted thiopyridones, generated either by cyclization of functionalized precursors, or by direct alkylation of the enolate of 2-methyl substituted pyrones. The most active compound in vitro against a strain of MRSA (A27223) displayed an MIC of 0.5 microg/mL. The most efficacious compound in vivo had a PD50 of 2.1 mg/kg.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
26
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
797-801
|
| pubmed:meshHeading |
pubmed-meshheading:11277523-Cephalosporins,
pubmed-meshheading:11277523-Methicillin Resistance,
pubmed-meshheading:11277523-Microbial Sensitivity Tests,
pubmed-meshheading:11277523-Pyridines,
pubmed-meshheading:11277523-Staphylococcus aureus,
pubmed-meshheading:11277523-Structure-Activity Relationship
|
| pubmed:year |
2001
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| pubmed:articleTitle |
Anti-MRSA cephems. Part 1: C-3 substituted thiopyridinium derivatives.
|
| pubmed:affiliation |
Anti-infective Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA. springed@bms.com
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| pubmed:publicationType |
Journal Article
|