Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-3-29
pubmed:abstractText
Leptospira interrogans are zoonotic pathogens that have been linked to a recent increased incidence of morbidity and mortality in highly populated tropical urban centers. They are unique among invasive spirochetes in that they contain outer membrane lipopolysaccharide (LPS) as well as lipoproteins. Here we show that both these leptospiral outer membrane constituents activate macrophages through CD14 and the Toll-like receptor 2 (TLR2). Conversely, it seems that TLR4, a central component for recognition of Gram-negative LPS, is not involved in cellular responses to L. interrogans. We also show that for intact L. interrogans, it is LPS, not lipoprotein, that constitutes the predominant signaling component for macrophages through a TLR2 pathway. These data provide a basis for understanding the innate immune response caused by leptospirosis and demonstrate a new ligand specificity for TLR2.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1529-2908
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
346-52
pubmed:dateRevised
2011-9-22
pubmed:meshHeading
pubmed-meshheading:11276206-Animals, pubmed-meshheading:11276206-Antigens, CD14, pubmed-meshheading:11276206-CHO Cells, pubmed-meshheading:11276206-Cell Line, pubmed-meshheading:11276206-Cricetinae, pubmed-meshheading:11276206-Drosophila Proteins, pubmed-meshheading:11276206-Humans, pubmed-meshheading:11276206-Leptospira interrogans, pubmed-meshheading:11276206-Leptospirosis, pubmed-meshheading:11276206-Lipopolysaccharides, pubmed-meshheading:11276206-Lipoproteins, pubmed-meshheading:11276206-Macrophage Activation, pubmed-meshheading:11276206-Membrane Glycoproteins, pubmed-meshheading:11276206-Mice, pubmed-meshheading:11276206-Mice, Knockout, pubmed-meshheading:11276206-Receptors, Cell Surface, pubmed-meshheading:11276206-Signal Transduction, pubmed-meshheading:11276206-Toll-Like Receptor 2, pubmed-meshheading:11276206-Toll-Like Receptor 4, pubmed-meshheading:11276206-Toll-Like Receptors
pubmed:year
2001
pubmed:articleTitle
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.
pubmed:affiliation
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't