Linked Life Data

11275308

Source:http://linkedlifedata.com/resource/pubmed/id/11275308

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-3-29
pubmed:abstractText
The Snail family of zinc-finger transcription factors is involved not only in the development of vertebrate and invertebrate embryos, but also in tumour progression. Following the identification of eight new members, we have analysed the evolutionary history of these genes and found that they constitute a superfamily that groups two independent families, Snail and Scratch. We propose that the duplication of an ancestral gene at the time of the metazoan radiation (1000-500 Myr ago) gave rise to Snail and Scratch, and that independent duplications in protostomes and deuterostomes led to the present situation. We discuss the implications of the distinct duplication events on the acquisition of new functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0168-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
178-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
The increasing complexity of the Snail gene superfamily in metazoan evolution.
pubmed:affiliation
Department of Developmental Neurobiology, Instituto Cajal, CSIC, Av. Doctor Arce 37, 28002, Madrid, Spain. manzanares@cajal.csic.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't