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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-3-29
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pubmed:abstractText |
The crucial role for CD28, its homolog CTLA-4 and their binding partners B7-1 and B7-2 in the generation of effective T-cell responses has been well documented. Recently, two new pairs of the CD28/B7 families were identified. The ability of these molecules to regulate T-cell expansion and effector function and the dynamic integration of the co-stimulatory and T-cell receptor signals are just beginning to be explored. Understanding these processes will be crucial for designing clinically relevant approaches to manipulate the adaptive immune system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CD86 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ICOS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Fc Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/PDCD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Receptor,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1471-4906
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
217-23
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11274928-Amino Acid Sequence,
pubmed-meshheading:11274928-Animals,
pubmed-meshheading:11274928-Antigens, CD,
pubmed-meshheading:11274928-Antigens, CD28,
pubmed-meshheading:11274928-Antigens, CD80,
pubmed-meshheading:11274928-Antigens, CD86,
pubmed-meshheading:11274928-Antigens, Differentiation,
pubmed-meshheading:11274928-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:11274928-Antigens, Surface,
pubmed-meshheading:11274928-Apoptosis Regulatory Proteins,
pubmed-meshheading:11274928-CTLA-4 Antigen,
pubmed-meshheading:11274928-Humans,
pubmed-meshheading:11274928-Immune Tolerance,
pubmed-meshheading:11274928-Immunoconjugates,
pubmed-meshheading:11274928-Immunoglobulin Fc Fragments,
pubmed-meshheading:11274928-Inducible T-Cell Co-Stimulator Protein,
pubmed-meshheading:11274928-Ligands,
pubmed-meshheading:11274928-Lymphocyte Activation,
pubmed-meshheading:11274928-Membrane Glycoproteins,
pubmed-meshheading:11274928-Models, Immunological,
pubmed-meshheading:11274928-Molecular Sequence Data,
pubmed-meshheading:11274928-Programmed Cell Death 1 Receptor,
pubmed-meshheading:11274928-Signal Transduction,
pubmed-meshheading:11274928-T-Lymphocytes
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pubmed:year |
2001
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pubmed:articleTitle |
The expanding world of co-stimulation: the two-signal model revisited.
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pubmed:affiliation |
Department of Pathology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA. cynthia.chambers@umassmed.edu
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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