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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-3-29
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pubmed:abstractText |
Prion replication in spleen and neuroinvasion after i.p. inoculation of mice is impaired in forms of immunodeficiency where mature B lymphocytes are lacking. In spleens of wild-type mice, infectivity is associated with B and T lymphocytes and stroma but not with circulating lymphocytes. We generated transgenic prion protein knockout mice overexpressing prion protein in B lymphocytes and found that they failed to accumulate prions in spleen after i.p. inoculation. We conclude that splenic B lymphocytes are not prion-replication competent and that they acquire prions from other cells, most likely follicular dendritic cells with which they closely associate and whose maturation depends on them.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-10097150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-10329617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-10545999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-10623745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-10818004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-10878556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-10888894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-1362440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-1376559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-1681118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-2569471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-3087759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-6408173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-6808890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-7494265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-7507207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-7515149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-7842304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-7916655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-7995952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-8094673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-8100741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-8635458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-8790598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-8917559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-9288968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-9363892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-9414161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-9529316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274428-9846583
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
pubmed-author:AguzziAA,
pubmed-author:CozzioAA,
pubmed-author:FlechsigEE,
pubmed-author:KleinM AMA,
pubmed-author:MontrasioFF,
pubmed-author:ProftJJ,
pubmed-author:RülickeTT,
pubmed-author:RaeberA JAJ,
pubmed-author:RossiDD,
pubmed-author:VosshenrichC ACA,
pubmed-author:WeissmannCC
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4034-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11274428-Animals,
pubmed-meshheading:11274428-B-Lymphocytes,
pubmed-meshheading:11274428-Central Nervous System,
pubmed-meshheading:11274428-Dendritic Cells, Follicular,
pubmed-meshheading:11274428-Mice,
pubmed-meshheading:11274428-Mice, Knockout,
pubmed-meshheading:11274428-Mice, Transgenic,
pubmed-meshheading:11274428-Prions,
pubmed-meshheading:11274428-Spleen
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pubmed:year |
2001
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pubmed:articleTitle |
B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice.
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pubmed:affiliation |
Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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