Linked Life Data

1127253

Source:http://linkedlifedata.com/resource/pubmed/id/1127253

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1975-8-4
pubmed:abstractText
Autoradography of rabbit intestine exposed in vivo to purified tritiated toxin of Vibrio cholerae showed that pharmacologically important amounts of toxin can be rapidly absorbed despite the relatively large size of the toxin molecule and its affinity for binding to the brush border. Cholera toxin and tritiated nontoxic and tritiated nontoxic control substances of comparable size followed a similar time course in spreading down the surface of the villus, and with respect to the villus greater than crypt gradient of labeling of cytoplasm of the mucosal epithelial cells. Absorption of toxin or biologically active toxin fragments provides a mechanism whereby the basal and lateral areas of the cell, which are rich in adenyl cyclase, could participate in the hypersecretory process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
210-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Kinetics of absorption of toxin of Vibrio cholerae.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.