Source:http://linkedlifedata.com/resource/pubmed/id/11272158
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2001-2-22
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| pubmed:abstractText |
Patients with diabetic neuropathy typically have decreased sweating in the feet but excessive sweating in the upper body. Previous studies of sudomotor function in diabetes have included patients with longstanding disease. The present study was designed to test for the early presence of sudomotor dysfunction and to characterize its relation to glycemic control and other aspects of peripheral nerve function. A total of 37 patients (10 males, 27 females) enrolled in a longitudinal study, in which autonomic function was evaluated annually for 3 years. Patients enrolled 2-22 months after the diagnosis of type 1 diabetes. Forty-one age- and sex-matched healthy control subjects were also studied. Sweat production in response to acetylcholine stimulation was dramatically increased in the forearm at the time of the first evaluation (1.67 +/- 0.24 micro/cm2 in the diabetic patients vs. 1.04 +/- 0.14 microl/cm2 in the control subjects, P < 0.05). Likewise, the ratio of sweating in the forearm to sweating below the waist was higher in the diabetic patients (0.553 +/- 0.07 microl/cm2) than in the control subjects (0.385 +/- 0.04 microl/cm2, P < 0.05). Forearm sweat was negatively associated with the renin-toprorenin ratio and vanillylmandelic acid (VMA) excretion (P < 0.025), tests of sympathetic nerve function. The ratio of sweating in the forearm to sweating in the foot was likewise increased in diabetic patients with poor glycemic control. We interpret this redistribution of sudomotor responses to be indicative of sympathetic nerve injury and conclude 1) that the sympathetic nervous system is especially vulnerable to the adverse effects of chronic hyperglycemia and 2) that sympathetic dysfunction can be detected very early in type 1 diabetes.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Renin,
http://linkedlifedata.com/resource/pubmed/chemical/Vanilmandelic Acid
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0012-1797
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
50
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
436-43
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:11272158-Acetylcholine,
pubmed-meshheading:11272158-Adolescent,
pubmed-meshheading:11272158-Adult,
pubmed-meshheading:11272158-Blood Glucose,
pubmed-meshheading:11272158-Child,
pubmed-meshheading:11272158-Diabetes Mellitus, Type 1,
pubmed-meshheading:11272158-Enzyme Precursors,
pubmed-meshheading:11272158-Female,
pubmed-meshheading:11272158-Foot,
pubmed-meshheading:11272158-Forearm,
pubmed-meshheading:11272158-Heart Rate,
pubmed-meshheading:11272158-Humans,
pubmed-meshheading:11272158-Longitudinal Studies,
pubmed-meshheading:11272158-Male,
pubmed-meshheading:11272158-Reference Values,
pubmed-meshheading:11272158-Renin,
pubmed-meshheading:11272158-Sweating,
pubmed-meshheading:11272158-Sympathetic Nervous System,
pubmed-meshheading:11272158-Thermosensing,
pubmed-meshheading:11272158-Time Factors,
pubmed-meshheading:11272158-Vanilmandelic Acid
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| pubmed:year |
2001
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| pubmed:articleTitle |
Redistribution of sudomotor responses is an early sign of sympathetic dysfunction in type 1 diabetes.
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| pubmed:affiliation |
Department of Medicine, West Virginia University, Morgantown, USA. rhoeldtke@hsc.wvu.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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