Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-3-28
pubmed:abstractText
Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0012-186X
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
237-40
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11270682-Adipose Tissue, pubmed-meshheading:11270682-Adult, pubmed-meshheading:11270682-Aged, pubmed-meshheading:11270682-Blood Glucose, pubmed-meshheading:11270682-Blood Pressure, pubmed-meshheading:11270682-C-Peptide, pubmed-meshheading:11270682-Denmark, pubmed-meshheading:11270682-Diabetes Mellitus, Type 2, pubmed-meshheading:11270682-European Continental Ancestry Group, pubmed-meshheading:11270682-Exons, pubmed-meshheading:11270682-Fasting, pubmed-meshheading:11270682-Gene Frequency, pubmed-meshheading:11270682-Humans, pubmed-meshheading:11270682-Insulin, pubmed-meshheading:11270682-Insulin Resistance, pubmed-meshheading:11270682-Middle Aged, pubmed-meshheading:11270682-Muscle, Skeletal, pubmed-meshheading:11270682-PTEN Phosphohydrolase, pubmed-meshheading:11270682-Phosphatidylinositol 3-Kinases, pubmed-meshheading:11270682-Phosphatidylinositol Phosphates, pubmed-meshheading:11270682-Phosphoric Monoester Hydrolases, pubmed-meshheading:11270682-Polymerase Chain Reaction, pubmed-meshheading:11270682-Polymorphism, Genetic, pubmed-meshheading:11270682-Polymorphism, Restriction Fragment Length, pubmed-meshheading:11270682-Polymorphism, Single-Stranded Conformational, pubmed-meshheading:11270682-Tumor Suppressor Proteins
pubmed:year
2001
pubmed:articleTitle
Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus.
pubmed:affiliation
Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't