rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-3-28
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pubmed:abstractText |
Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a novel member in the expanding network of proteins regulating the intracellular effects of insulin. By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue. In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/PTEN Phosphohydrolase,
http://linkedlifedata.com/resource/pubmed/chemical/PTEN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Monoester Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/phosphatidylinositol...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
237-40
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11270682-Adipose Tissue,
pubmed-meshheading:11270682-Adult,
pubmed-meshheading:11270682-Aged,
pubmed-meshheading:11270682-Blood Glucose,
pubmed-meshheading:11270682-Blood Pressure,
pubmed-meshheading:11270682-C-Peptide,
pubmed-meshheading:11270682-Denmark,
pubmed-meshheading:11270682-Diabetes Mellitus, Type 2,
pubmed-meshheading:11270682-European Continental Ancestry Group,
pubmed-meshheading:11270682-Exons,
pubmed-meshheading:11270682-Fasting,
pubmed-meshheading:11270682-Gene Frequency,
pubmed-meshheading:11270682-Humans,
pubmed-meshheading:11270682-Insulin,
pubmed-meshheading:11270682-Insulin Resistance,
pubmed-meshheading:11270682-Middle Aged,
pubmed-meshheading:11270682-Muscle, Skeletal,
pubmed-meshheading:11270682-PTEN Phosphohydrolase,
pubmed-meshheading:11270682-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:11270682-Phosphatidylinositol Phosphates,
pubmed-meshheading:11270682-Phosphoric Monoester Hydrolases,
pubmed-meshheading:11270682-Polymerase Chain Reaction,
pubmed-meshheading:11270682-Polymorphism, Genetic,
pubmed-meshheading:11270682-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:11270682-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:11270682-Tumor Suppressor Proteins
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pubmed:year |
2001
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pubmed:articleTitle |
Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus.
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pubmed:affiliation |
Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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