Linked Life Data

11269507

Source:http://linkedlifedata.com/resource/pubmed/id/11269507

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2001-3-27
pubmed:abstractText
Tumor gene therapy is potentially very specific and efficacious. Suicide genes are promising tools in the arsenal of tumor gene therapy. However, problems of tumor targeting, low in vivo efficacy of nucleic acid transfer, and recent reports of adverse effects hinder the translation of this approach into clinical practice. Therefore vector design, tumor targeting, mechanisms of cell kill and killing of untransfected tumor cells must be improved. Once these problems are solved in vitro and in animal models, gene therapy holds great promise for pediatric oncology given the abundance of specific targets in pediatric tumors. This review describes the current state of preclinical research in tumor suicide gene therapy, provides an outline of pediatric suicide gene therapy protocols, and identifies potential targets in pediatric malignancies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0946-2716
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
598-612
pubmed:dateRevised
2011-7-8
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Suicide gene therapy for pediatric tumors.
pubmed:affiliation
Universitäts-Kinderklinik Ulm, Germany. christian.beltinger@medizin.uni-ulm.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't